Literature DB >> 347574

Schizophrenic symptoms improve with apomorphine.

C A Tamminga, M H Schaffer, R C Smith, J M Davis.   

Abstract

Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.

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Year:  1978        PMID： 347574     DOI： 10.1126/science.347574

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  31 in total

Review 1.  Apomorphine and the dopamine hypothesis of schizophrenia: a dilemma?

Authors:  L Dépatie; S Lal
Journal:  J Psychiatry Neurosci       Date:  2001-05       Impact factor: 6.186

2.  Stimulation of D2 receptors in the prefrontal cortex reduces PCP-induced hyperactivity, acetylcholine release and dopamine metabolism in the nucleus accumbens.

Authors:  A Del Arco; F Mora; A H Mohammed; K Fuxe
Journal:  J Neural Transm (Vienna)       Date:  2006-08-08       Impact factor: 3.575

3.  Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder.

Authors:  Hamid Mostafavi Abdolmaleky; Kuang-Hung Cheng; Stephen V Faraone; Marsha Wilcox; Stephen J Glatt; Fangming Gao; Cassandra L Smith; Rahim Shafa; Batol Aeali; Julie Carnevale; Hongjie Pan; Panagiotis Papageorgis; Jose F Ponte; Vadivelu Sivaraman; Ming T Tsuang; Sam Thiagalingam
Journal:  Hum Mol Genet       Date:  2006-09-19       Impact factor: 6.150

Review 4.  GPCR functional selectivity has therapeutic impact.

Authors:  Richard B Mailman
Journal:  Trends Pharmacol Sci       Date:  2007-07-13       Impact factor: 14.819

5.  Effects of apomorphine and haloperidol on "spontaneous" stereotyped licking behaviour in the Cebus monkey.

Authors:  S Korsgaard; U J Povlsen; A Randrup
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

Review 6.  Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia.

Authors:  A A Grace
Journal:  J Neural Transm Gen Sect       Date:  1993

7.  Differential effects of 3-PPP enantiomers on extracellular dopamine concentration in the caudate-putamen and nucleus accumbens of rats.

Authors:  R E See
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-12       Impact factor: 3.000

Review 8.  Third generation antipsychotic drugs: partial agonism or receptor functional selectivity?

Authors:  Richard B Mailman; Vishakantha Murthy
Journal:  Curr Pharm Des       Date:  2010       Impact factor: 3.116

9.  Pharmacologic properties of (-)-3PPP (preclamol) in man.

Authors:  C A Tamminga; N G Cascella; R A Lahti; M Lindberg; A Carlsson
Journal:  J Neural Transm Gen Sect       Date:  1992

10.  Local and distributed effects of apomorphine on fronto-temporal function in acute unmedicated schizophrenia.

Authors:  P C Fletcher; C D Frith; P M Grasby; K J Friston; R J Dolan
Journal:  J Neurosci       Date:  1996-11-01       Impact factor: 6.167
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