Literature DB >> 34756581

Pemphigus and Pemphigoid: From Disease Mechanisms to Druggable Pathways.

Christoph T Ellebrecht1, Damian Maseda1, Aimee S Payne2.   

Abstract

Pemphigus and pemphigoid are paradigms for understanding the mechanisms of antibody-mediated autoimmune disease in humans. In pemphigus, IgG4-predominant autoantibodies cause intraepidermal blistering by direct interference with desmoglein interactions and subsequent disruption of desmosomes and signaling pathways. In pemphigoid, IgG1, IgG4, and IgE autoantibodies against basement membrane zone antigens directly interfere with hemidesmosomal adhesion, activating complement and Fc receptor‒mediated effector pathways. Unraveling disease mechanisms in pemphigus and pemphigoid has identified numerous opportunities for clinical trials, which hold promise to identify safer and more effective therapies for these potentially life-threatening diseases.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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Year:  2021        PMID： 34756581      PMCID： PMC8860856          DOI： 10.1016/j.jid.2021.04.040

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   7.590


  98 in total

1.  Effect of plasmapheresis therapy on circulating levels of pemphigus antibodies.

Authors:  R Tan-Lim; J C Bystryn
Journal:  J Am Acad Dermatol       Date:  1990-01       Impact factor: 11.527

2.  Enzyme-linked immunosorbent assay using bacterial recombinant proteins of human BP230 as a diagnostic tool for bullous pemphigoid.

Authors:  Mariko Yoshida; Takahiro Hamada; Masayuki Amagai; Koji Hashimoto; Rie Uehara; Kentaro Yamaguchi; Koji Imamura; Eiji Okamoto; Shinichiro Yasumoto; Takashi Hashimoto
Journal:  J Dermatol Sci       Date:  2005-12-20       Impact factor: 4.563

3.  A successful treatment with ustekinumab in a case of relapsing bullous pemphigoid associated with psoriasis.

Authors:  J Loget; J Plée; F Antonicelli; P Bernard
Journal:  J Eur Acad Dermatol Venereol       Date:  2016-11-07       Impact factor: 6.166

4.  Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering.

Authors:  Kenji Yoshida; Ken Ishii; Atsushi Shimizu; Mariko Yokouchi; Masayuki Amagai; Ken Shiraishi; Yuji Shirakata; John R Stanley; Akira Ishiko
Journal:  J Dermatol Sci       Date:  2016-12-12       Impact factor: 4.563

5.  Comparison of C3d immunohistochemical staining to enzyme-linked immunosorbent assay and immunofluorescence for diagnosis of bullous pemphigoid.

Authors:  Leo L Wang; Ata S Moshiri; Roberto Novoa; Cory L Simpson; Junko Takeshita; Aimee S Payne; Emily Y Chu
Journal:  J Am Acad Dermatol       Date:  2020-02-14       Impact factor: 11.527

6.  Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies.

Authors:  Ken Ishii; Chenyan Lin; Don L Siegel; John R Stanley
Journal:  J Invest Dermatol       Date:  2007-11-15       Impact factor: 8.551

7.  Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia.

Authors:  Shannon L Maude; Theodore W Laetsch; Jochen Buechner; Susana Rives; Michael Boyer; Henrique Bittencourt; Peter Bader; Michael R Verneris; Heather E Stefanski; Gary D Myers; Muna Qayed; Barbara De Moerloose; Hidefumi Hiramatsu; Krysta Schlis; Kara L Davis; Paul L Martin; Eneida R Nemecek; Gregory A Yanik; Christina Peters; Andre Baruchel; Nicolas Boissel; Francoise Mechinaud; Adriana Balduzzi; Joerg Krueger; Carl H June; Bruce L Levine; Patricia Wood; Tetiana Taran; Mimi Leung; Karen T Mueller; Yiyun Zhang; Kapildeb Sen; David Lebwohl; Michael A Pulsipher; Stephan A Grupp
Journal:  N Engl J Med       Date:  2018-02-01       Impact factor: 91.245

8.  Bullous pemphigoid during ustekinumab therapy.

Authors:  Aurore Le Guern; Salim Alkeraye; Annie Vermersch-Langlin; Patrick Coupe; Marlène Vonarx
Journal:  JAAD Case Rep       Date:  2015-10-02

9.  Autoreactive IgG and IgA B Cells Evolve through Distinct Subclass Switch Pathways in the Autoimmune Disease Pemphigus Vulgaris.

Authors:  Christoph T Ellebrecht; Eric M Mukherjee; Qi Zheng; Eun Jung Choi; Shantan G Reddy; Xuming Mao; Aimee S Payne
Journal:  Cell Rep       Date:  2018-08-28       Impact factor: 9.423

10.  Single-Cell Analysis Suggests that Ongoing Affinity Maturation Drives the Emergence of Pemphigus Vulgaris Autoimmune Disease.

Authors:  Alice Cho; Amber L Caldara; Nina A Ran; Zach Menne; Robert C Kauffman; Maurizio Affer; Alexandra Llovet; Carson Norwood; Aaron Scanlan; Grace Mantus; Bridget Bradley; Stephanie Zimmer; Thomas Schmidt; Michael Hertl; Aimee S Payne; Ron Feldman; Andrew P Kowalczyk; Jens Wrammert
Journal:  Cell Rep       Date:  2019-07-23       Impact factor: 9.423
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  2 in total

Review 1.  Immunotherapy for Pemphigus: Present and Future.

Authors:  Huijie Yuan; Meng Pan; Hongxiang Chen; Xuming Mao
Journal:  Front Med (Lausanne)       Date:  2022-06-15

Review 2.  Mechanisms Causing Acantholysis in Pemphigus-Lessons from Human Skin.

Authors:  Desalegn Tadesse Egu; Thomas Schmitt; Jens Waschke
Journal:  Front Immunol       Date:  2022-05-20       Impact factor: 8.786
  2 in total

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