Fatemeh Samiee1, Reza Mohammadi2, Sadegh Shirian3,4,5, Mohammad-Reza Alijani3, Azita Aledavood4, Shahrzad Negahban4, Amir Ghaemi6, Khosrow Daneshbod4, Yahya Daneshbod4,7. 1. Department of Pathology, Qazvin Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran, Bahonar St, Qazvin, Iran. 2. Department of Medical Genetics, Shiraz Infertility Treatment Center, Shiraz, Iran, Zand St, Shiraz 7134777108, Iran. 3. Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran, Rahbar St, Shahrekord 8818634141, Iran. 4. Shiraz Molecular Pathology Research Center, Dr Daneshbod Pathology Laboratory, Shiraz, Iran, Eastern Ordibehesht, Zand St, Shiraz 7134777118, Iran. 5. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. 6. Department of Virology, Pasteur Institute of Iran, Farvardin St, Tehran 1316943551, Iran. 7. Department of Pathology & Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA 92354, USA.
Abstract
Background: Lymphoma, both Hodgkin and non-Hodgkin, is one of the most common malignancies, with a distinct subtype distribution throughout the world. Methods: A total of 453 lymphoma cases, identified retrospectively from January 2000 to October 2011, were studied to identify the subtype distribution of lymphoma in our center, located in southern Iran, according to the latest WHO classification. Results: The most common sites of involvement of all lymphomas were extranodal (59.16%). The highest frequency of extranodal sites in all lymphoid neoplasms were associated with diffuse large B-cell lymphoma (22.95%) and classical Hodgkin lymphoma (10.15%). Of 453 cases, 23 (5.32%) were T and natural killer cell neoplasms, of which the most common subtypes were T-cell large granular lymphocytic leukemia and anaplastic large cell lymphoma. Conclusion: This study indicated that the subtype distribution of lymphoma (except for the higher prevalence of diffuse large B-cell lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma and lower rate of follicular lymphoma) in this part of Iran is similar to that in the Middle Eastern countries. Mature B-cell neoplasms are less frequent compared with both western and far east Asian countries.
Background: Lymphoma, both Hodgkin and non-Hodgkin, is one of the most common malignancies, with a distinct subtype distribution throughout the world. Methods: A total of 453 lymphoma cases, identified retrospectively from January 2000 to October 2011, were studied to identify the subtype distribution of lymphoma in our center, located in southern Iran, according to the latest WHO classification. Results: The most common sites of involvement of all lymphomas were extranodal (59.16%). The highest frequency of extranodal sites in all lymphoid neoplasms were associated with diffuse large B-cell lymphoma (22.95%) and classical Hodgkin lymphoma (10.15%). Of 453 cases, 23 (5.32%) were T and natural killer cell neoplasms, of which the most common subtypes were T-cell large granular lymphocytic leukemia and anaplastic large cell lymphoma. Conclusion: This study indicated that the subtype distribution of lymphoma (except for the higher prevalence of diffuse large B-cell lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma and lower rate of follicular lymphoma) in this part of Iran is similar to that in the Middle Eastern countries. Mature B-cell neoplasms are less frequent compared with both western and far east Asian countries.
Entities:
Keywords:
WHO classification; lymphoma; lymphoma distribution; subtypes