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Literature DB >> 34753606

MicroRNA regulation of critical retinal pigment epithelial functions.

Abstract

MicroRNAs are short, evolutionarily conserved noncoding RNAs that are critical for the control of normal cellular physiology. In the retina, photoreceptors are highly specialized neurons that transduce light into electrical signals. Photoreceptors, however, are unable to process visual stimuli without the support of the retinal pigment epithelium (RPE). The RPE performs numerous functions to aid the retina, including the generation of visual chromophore and metabolic support. Recent work has underscored how microRNAs enable vision through their contributions to RPE functions. This review focuses on the biogenesis and control of microRNAs in rodents and humans, the roles microRNAs play in RPE function and degeneration, and how microRNAs could serve as potential therapeutics and biomarkers for visual diseases.

Entities: Chemical

Keywords: biomarker; exosome; gene therapy; noncoding RNA; oxidative stress; phagocytosis

Mesh：

Substances：

Year: 2021 PMID： 34753606 PMCID： PMC9066699 DOI： 10.1016/j.tins.2021.10.008

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 16.978

113 in total

1. MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells.

Authors: Jingjing Cai; He Zhang; Yun-Feng Zhang; Zhonglou Zhou; Shengzhou Wu
Journal: Exp Cell Res Date: 2018-12-01 Impact factor: 3.905

Review 2. PEDF: a multifaceted neurotrophic factor.

Authors: Joyce Tombran-Tink; Colin J Barnstable
Journal: Nat Rev Neurosci Date: 2003-08 Impact factor: 34.870

3. miR-204 is required for lens and retinal development via Meis2 targeting.

Authors: Ivan Conte; Sabrina Carrella; Raffaella Avellino; Marianthi Karali; Raquel Marco-Ferreres; Paola Bovolenta; Sandro Banfi
Journal: Proc Natl Acad Sci U S A Date: 2010-08-16 Impact factor: 11.205

4. MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation.

Authors: Ulf Andersson Ørom; Finn Cilius Nielsen; Anders H Lund
Journal: Mol Cell Date: 2008-05-23 Impact factor: 17.970

5. Investigation of circRNA Expression Profiles and Analysis of circRNA-miRNA-mRNA Networks in an Animal (Mouse) Model of Age-Related Macular Degeneration.

Authors: Xiao Liu; Liwei Zhang; Jiang-Hui Wang; Huilan Zeng; Jingling Zou; Wei Tan; Han Zhao; Yan He; Jingming Shi; Shigeo Yoshida; Yunping Li; Yedi Zhou
Journal: Curr Eye Res Date: 2020-01-24 Impact factor: 2.424

6. Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision.

Authors: Eduardo Zabala Aldunate; Valentina Di Foggia; Fabiana Di Marco; Laura Abelleira Hervas; Joana Claudio Ribeiro; Daniel L Holder; Aara Patel; Tommaso B Jannini; Dorothy A Thompson; Juan Pedro Martinez-Barbera; Rachael A Pearson; Robin R Ali; Jane C Sowden
Journal: Sci Rep Date: 2019-02-19 Impact factor: 4.379

7. miR-181a/b downregulation exerts a protective action on mitochondrial disease models.

Authors: Alessia Indrieri; Sabrina Carrella; Alessia Romano; Alessandra Spaziano; Elena Marrocco; Erika Fernandez-Vizarra; Sara Barbato; Mariateresa Pizzo; Yulia Ezhova; Francesca M Golia; Ludovica Ciampi; Roberta Tammaro; Jorge Henao-Mejia; Adam Williams; Richard A Flavell; Elvira De Leonibus; Massimo Zeviani; Enrico M Surace; Sandro Banfi; Brunella Franco
Journal: EMBO Mol Med Date: 2019-05 Impact factor: 14.260

8. NFE2/miR-423-5p/TFF1 axis regulates high glucose-induced apoptosis in retinal pigment epithelial cells.

Authors: Qing Xiao; Yinu Zhao; Jia Xu; Wen-Jie Li; Yu Chen; Hong-Jing Sun
Journal: BMC Mol Cell Biol Date: 2019-08-27

9. Direct conversion of adult human retinal pigmented epithelium cells to neurons with photoreceptor properties.

Authors: Bo Li; Houbo Jiang; Hong Li; Boyang Zhang; Malcolm Slaughter; Zhen Yan; Jian Feng
Journal: Exp Biol Med (Maywood) Date: 2020-10-18

10. Interleukin-6 promotes proliferative vitreoretinopathy by inducing epithelial-mesenchymal transition via the JAK1/STAT3 signaling pathway.

Authors: Xiaoyun Chen; Weimin Yang; Xiaoqian Deng; Shaobi Ye; Wei Xiao
Journal: Mol Vis Date: 2020-07-29 Impact factor: 2.367

4 in total

Review 1. MicroRNAs as Regulators of Phagocytosis.

Authors: Wojciech Gierlikowski; Barbara Gierlikowska
Journal: Cells Date: 2022-04-19 Impact factor: 7.666

Review 2. MicroRNAs Are Key Molecules Involved in the Gene Regulation Network of Colorectal Cancer.

Authors: Fangfang Yang; Guoyun Xuan; Yixin Chen; Lichao Cao; Min Zhao; Chen Wang; Erfei Chen
Journal: Front Cell Dev Biol Date: 2022-04-08

Review 3. Update of application of olfactory ensheathing cells and stem cells/exosomes in the treatment of retinal disorders.

Authors: Yang Yu; Licheng Li; Shu Lin; Jianmin Hu
Journal: Stem Cell Res Ther Date: 2022-01-10 Impact factor: 6.832

Review 4. The Role of microRNA in the Inflammatory Response of Wound Healing.

Authors: Yuanyuan Jiang; Xiang Xu; Long Xiao; Lihong Wang; Sheng Qiang
Journal: Front Immunol Date: 2022-03-21 Impact factor: 7.561

4 in total