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Literature DB >> 3475233

The cDNA sequence and gene analysis of the human pim oncogene.

R Zakut-Houri, S Hazum, D Givol, A Telerman.

Abstract

The putative oncogene pim-1 is frequently activated by provirus insertion in MuLV-induced T cell lymphomas in mice. By analogy with other cellular oncogenes that are similarly activated (e.g., myc, myb, erbB) it is possible that pim-1 may also be involved in some human tumors. To study human pim-1 we cloned and sequenced human pim-1 cDNA clones. The human pim-1 codes for a protein of 313 amino acids (aa) which is highly homologous (94%) to the deduced amino acid sequence of mouse pim-1. All the mouse pim-1 residues which are homologous to protein kinases are conserved in the human pim-1. We also isolated the human pim-1 gene and mapped it relative to the cDNA. The RNA transcript of human pim-1 is approx. 3.0 kb and it is highly expressed in the erythroleukemia cell line K562.

Entities: Disease Gene Species

Mesh：

Substances：
DNA

Year: 1987 PMID： 3475233 DOI： 10.1016/0378-1119(87)90352-0

Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688

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Cited

10 in total

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5. RPK1, an essential yeast protein kinase involved in the regulation of the onset of mitosis, shows homology to mammalian dual-specificity kinases.

Authors: O Poch; E Schwob; F de Fraipont; A Camasses; R Bordonné; R P Martin
Journal: Mol Gen Genet Date: 1994-06-15

The cDNA sequence and gene analysis of the human pim oncogene.

1. Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms.

2. Isolation of interleukin 2-induced immediate-early genes.

3. Detecting high-resolution polymorphisms in human coding loci by combining PCR and single-strand conformation polymorphism (SSCP) analysis.

4. Three adjacent genes of African swine fever virus with similarity to essential poxvirus genes.

5. RPK1, an essential yeast protein kinase involved in the regulation of the onset of mitosis, shows homology to mammalian dual-specificity kinases.

6. Identification of the human pim-1 gene product as a 33-kilodalton cytoplasmic protein with tyrosine kinase activity.

7. The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias.

8. The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG.

9. Pim-1 levels determine the size of early B lymphoid compartments in bone marrow.

10. PIM-1 kinase: a potential biomarker of triple-negative breast cancer.