Literature DB >> 34752055

Benzimidazole Isosteres of Salicylanilides Are Highly Active Colistin Adjuvants.

Haoting Li1, Anne E Mattingly1, Leigh A Jania2, Richard Smith3, Roberta J Melander1, Robert K Ernst3, Beverley H Koller2, Christian Melander1.   

Abstract

Multidrug-resistant bacterial infections have become a global threat. We recently disclosed that the known IKK-β inhibitor IMD-0354 and subsequent analogues abrogate colistin resistance in several Gram-negative strains. Herein, we report the activity of a second-generation library of IMD-0354 analogues incorporating a benzimidazole moiety as an amide isostere. We identified several analogues that show increased colistin potentiation activity against Gram-negative bacteria.

Entities:  

Keywords:  Acinetobacter baumannii; Klebsiella pneumoniae; antibiotic adjuvant; colistin resistance

Mesh：

Substances：

Year:  2021        PMID： 34752055      PMCID： PMC8958665          DOI： 10.1021/acsinfecdis.1c00463

Source DB:  PubMed          Journal:  ACS Infect Dis        ISSN： 2373-8227            Impact factor:   5.084


  26 in total

Review 1.  Antibacterial drug discovery in the resistance era.

Authors:  Eric D Brown; Gerard D Wright
Journal:  Nature       Date:  2016-01-21       Impact factor: 49.962

2.  Sensitization of Gram-negative bacteria to antibiotics and complement by a nontoxic oligopeptide.

Authors:  M Vaara; T Vaara
Journal:  Nature       Date:  1983 Jun 9-15       Impact factor: 49.962

3.  Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus.

Authors:  Roger L Nation; Jian Li; Otto Cars; William Couet; Michael N Dudley; Keith S Kaye; Johan W Mouton; David L Paterson; Vincent H Tam; Ursula Theuretzbacher; Brian T Tsuji; John D Turnidge
Journal:  Lancet Infect Dis       Date:  2014-10-21       Impact factor: 25.071

4.  The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?

Authors:  Roberta J Melander; Christian Melander
Journal:  ACS Infect Dis       Date:  2017-05-26       Impact factor: 5.084

5.  Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-Negative Bacteria.

Authors:  William T Barker; Ansley M Nemeth; Sara M Brackett; Akash K Basak; Courtney E Chandler; Leigh A Jania; William J Zuercher; Roberta J Melander; Beverly H Koller; Robert K Ernst; Christian Melander
Journal:  ACS Infect Dis       Date:  2019-09-04       Impact factor: 5.084

6.  Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar typhimurium.

Authors:  J S Gunn; S S Ryan; J C Van Velkinburgh; R K Ernst; S I Miller
Journal:  Infect Immun       Date:  2000-11       Impact factor: 3.441

7.  Structure-Function Studies on IMD-0354 Identifies Highly Active Colistin Adjuvants.

Authors:  Ansley M Nemeth; Akash K Basak; Alexander W Weig; Santiana A Marrujo; William T Barker; Leigh A Jania; Tyler A Hendricks; Ashley E Sullivan; Patrick M O'Connor; Roberta J Melander; Beverly H Koller; Christian Melander
Journal:  ChemMedChem       Date:  2019-12-04       Impact factor: 3.466

8.  Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane.

Authors:  Akshay Sabnis; Katheryn Lh Hagart; Anna Klöckner; Michele Becce; Lindsay E Evans; R Christopher D Furniss; Despoina Ai Mavridou; Ronan Murphy; Molly M Stevens; Jane C Davies; Gérald J Larrouy-Maumus; Thomas B Clarke; Andrew M Edwards
Journal:  Elife       Date:  2021-04-06       Impact factor: 8.140

9.  Screening an Established Natural Product Library Identifies Secondary Metabolites That Potentiate Conventional Antibiotics.

Authors:  Anne E Mattingly; Karlie E Cox; Richard Smith; Roberta J Melander; Robert K Ernst; Christian Melander
Journal:  ACS Infect Dis       Date:  2020-09-11       Impact factor: 5.084

10.  ent-Beyerane Diterpenes as a Key Platform for the Development of ArnT-Mediated Colistin Resistance Inhibitors.

Authors:  Deborah Quaglio; Maria Luisa Mangoni; Roberta Stefanelli; Silvia Corradi; Bruno Casciaro; Valeria Vergine; Federica Lucantoni; Luca Cavinato; Silvia Cammarone; Maria Rosa Loffredo; Floriana Cappiello; Andrea Calcaterra; Silvia Erazo; Francesca Ghirga; Mattia Mori; Francesco Imperi; Fiorentina Ascenzioni; Bruno Botta
Journal:  J Org Chem       Date:  2020-08-10       Impact factor: 4.354
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