Morgan Birabaharan1, Andrew Strunk2, David C Kaelber3,4, Davey M Smith1,5, Thomas C S Martin1,5. 1. Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, California. 2. Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York. 3. Departments of Internal Medicine, Pediatrics, and Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University. 4. Center for Clinical Informatics Research and Education, The MetroHealth System, Cleveland, Ohio. 5. San Diego Veterans Affairs Healthcare System, San Diego, California, USA.
Abstract
OBJECTIVE: To examine whether type 2 diabetes mellitus (T2DM) is more common among women with HIV (WWH) than men with HIV (MWH). DESIGN: A cross-sectional analysis of a demographically heterogenous population-based sample of more than 64 million patients in the United States. METHODS: Using the Explorys (IBM) database, compare the prevalence of T2DM among men and women without HIV and influence of HIV on T2DM by sex controlling for confounding factors. RESULTS: From 19 182 775 persons included in the study, 39 485 were with HIV. Rates of obesity was higher among WWH than MWH (58 vs. 35%). Prevalence of T2DM among WWH was 23% compared with 16% among MWH (P < 0.001). In sex-stratified adjusted analysis, WWH had 1.31 [95% confidence interval (CI), 1.24-1.38] times the odds of having T2DM than women without HIV. Women with HIV was associated with T2DM across all demographic subgroups. In contrast, no association between HIV and T2DM was observed among men (OR 1.01; 95% CI 0.98-1.05). CONCLUSION: These data suggest that HIV confers a sex-specific increase in odds of T2DM among women but not men.
OBJECTIVE: To examine whether type 2 diabetes mellitus (T2DM) is more common among women with HIV (WWH) than men with HIV (MWH). DESIGN: A cross-sectional analysis of a demographically heterogenous population-based sample of more than 64 million patients in the United States. METHODS: Using the Explorys (IBM) database, compare the prevalence of T2DM among men and women without HIV and influence of HIV on T2DM by sex controlling for confounding factors. RESULTS: From 19 182 775 persons included in the study, 39 485 were with HIV. Rates of obesity was higher among WWH than MWH (58 vs. 35%). Prevalence of T2DM among WWH was 23% compared with 16% among MWH (P < 0.001). In sex-stratified adjusted analysis, WWH had 1.31 [95% confidence interval (CI), 1.24-1.38] times the odds of having T2DM than women without HIV. Women with HIV was associated with T2DM across all demographic subgroups. In contrast, no association between HIV and T2DM was observed among men (OR 1.01; 95% CI 0.98-1.05). CONCLUSION: These data suggest that HIV confers a sex-specific increase in odds of T2DM among women but not men.
Authors: Todd T Brown; Stephen R Cole; Xiuhong Li; Lawrence A Kingsley; Frank J Palella; Sharon A Riddler; Barbara R Visscher; Joseph B Margolick; Adrian S Dobs Journal: Arch Intern Med Date: 2005-05-23
Authors: Devon W Paul; Nigel B Neely; Meredith Clement; Isaretta Riley; Mashael Al-Hegelan; Matthew Phelan; Monica Kraft; David M Murdoch; Joseph Lucas; John Bartlett; Mehri McKellar; Loretta G Que Journal: J Am Med Inform Assoc Date: 2018-02-01 Impact factor: 4.497
Authors: Matthew A Spinelli; Edward A Frongillo; Lila A Sheira; Kartika Palar; Phyllis C Tien; Tracey Wilson; Daniel Merenstein; Mardge Cohen; Adebola Adedimeji; Eryka Wentz; Adaora A Adimora; Lisa R Metsch; Janet M Turan; Margot B Kushel; Sheri D Weiser Journal: AIDS Behav Date: 2017-12
Authors: Randi E Foraker; Kathryn M Rose; Eric A Whitsel; Chirayath M Suchindran; Joy L Wood; Wayne D Rosamond Journal: BMC Public Health Date: 2010-10-21 Impact factor: 3.295
Authors: Paul E Sax; Kristine M Erlandson; Jordan E Lake; Grace A Mccomsey; Chloe Orkin; Stefan Esser; Todd T Brown; Jürgen K Rockstroh; Xuelian Wei; Christoph C Carter; Lijie Zhong; Diana M Brainard; Kathleen Melbourne; Moupali Das; Hans-Jürgen Stellbrink; Frank A Post; Laura Waters; John R Koethe Journal: Clin Infect Dis Date: 2020-09-12 Impact factor: 9.079