Literature DB >> 34750068

Pathogenic role and therapeutic potential of fibro-adipogenic progenitors in muscle disease.

Marshall W Hogarth1, Prech Uapinyoying2, Davi A G Mázala3, Jyoti K Jaiswal4.   

Abstract

Aside from myofibers, numerous mononucleated cells reside in the skeletal muscle. These include the mesenchymal cells called fibro-adipogenic progenitors (FAPs), that support muscle development and regeneration in adult muscles. Recent evidence shows that defects in FAP function contributes to chronic muscle diseases and targeting FAPs offers avenues for treating these diseases.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  adipogenesis; fibrosis; injury; muscular dystrophy; osteogenesis; stromal cells

Mesh：

Year:  2021        PMID： 34750068     DOI： 10.1016/j.molmed.2021.10.003

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  2 in total

1.  Unraveling the Molecular Basis of the Dystrophic Process in Limb-Girdle Muscular Dystrophy LGMD-R12 by Differential Gene Expression Profiles in Diseased and Healthy Muscles.

Authors:  Christophe E Depuydt; Veerle Goosens; Rekin's Janky; Ann D'Hondt; Jan L De Bleecker; Nathalie Noppe; Stefaan Derveaux; Dietmar R Thal; Kristl G Claeys
Journal:  Cells       Date:  2022-04-30       Impact factor: 7.666

2.  Non-myogenic mesenchymal cells contribute to muscle degeneration in facioscapulohumeral muscular dystrophy patients.

Authors:  Lorena Di Pietro; Flavia Giacalone; Elvira Ragozzino; Valentina Saccone; Federica Tiberio; Marco De Bardi; Mario Picozza; Giovanna Borsellino; Wanda Lattanzi; Enrico Guadagni; Sara Bortolani; Giorgio Tasca; Enzo Ricci; Ornella Parolini
Journal:  Cell Death Dis       Date:  2022-09-16       Impact factor: 9.685
  2 in total

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