Jonathan I Silverberg1, Alexander Hou2, Erin M Warshaw3,4,5, Howard I Maibach6, Donald V Belsito7, Joel G DeKoven8, Kathryn A Zug9, James S Taylor10, Denis Sasseville11, Anthony F Fransway12, Vincent A DeLeo13, Melanie D Pratt14, Margo J Reeder15, Amber R Atwater16, Joseph F Fowler17, Matthew J Zirwas18, James G Marks19. 1. Department of Dermatology, School of Medicine, George Washington University, 2150 Pennsylvania Avenue, Suite 2B-425, Washington, DC, 20037, USA. jonathanisilverberg@gmail.com. 2. Department of Dermatology, Feinberg School of Medicine, Northwestern University, Evanston, USA. 3. Department of Dermatology, Park Nicollet Health Services, Minneapolis, MN, USA. 4. Department of Dermatology, University of Minnesota, Minneapolis, MN, USA. 5. Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, USA. 6. Department of Dermatology, University of California San Francisco, San Francisco, USA. 7. Department of Dermatology, Columbia University Irving Medical Center, New York, NY, USA. 8. Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. 9. Department of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA. 10. Department of Dermatology, Cleveland Clinic, Cleveland, OH, USA. 11. Division of Dermatology, Montreal General Hospital, McGill University, Montreal, QC, Canada. 12. Associates in Dermatology, Fort Myers, FL, USA. 13. Department of Dermatology, Keck School of Medicine, Los Angeles, CA, USA. 14. Division of Dermatology, University of Ottawa, Ottawa, ON, Canada. 15. Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. 16. Department of Dermatology, Duke University Medical Center, Durham, NC, USA. 17. Division of Dermatology, University of Louisville, Louisville, KY, USA. 18. Department of Dermatology, Ohio State University, Columbus, USA. 19. Department of Dermatology, Pennsylvania State University, State College, USA.
Abstract
BACKGROUND: Few studies explored the relationship between stasis dermatitis (SD) and allergic contact dermatitis (ACD). OBJECTIVE: To examine trends, associations, and clinical relevance of ACD in patients referred for patch testing who had a final SD diagnosis. METHODS: Retrospective analysis from 2001 to 2016 of 38,723 patients from the North American Contact Dermatitis Group. RESULTS: After patch testing, 303 (0.7%) patients were diagnosed with SD; 46.7% had a concomitant diagnosis of ACD. Patients with vs. without a final SD diagnosis had similar proportions of ≥ 1 positive allergic reaction (59.7% vs. 64.7%; Chi-square, P = 0.0724) but higher odds of allergic reactions to fragrance mix I, bacitracin, quaternium-15, Myroxylon pereirae, benzalkonium chloride, ethyleneurea melamine formaldehyde, diazolidinyl urea, and propylene glycol. The most commonly relevant allergens in patients with final SD diagnosis were fragrance mix I, Myroxylon pereirae, bacitracin, quaternium-15, and formaldehyde. The most common allergen sources were personal care products, topical medications and other health aid products. CONCLUSION: Nearly half of patients with a final SD diagnosis were also diagnosed with ACD, supporting the role of patch testing in select SD patients.
BACKGROUND: Few studies explored the relationship between stasis dermatitis (SD) and allergic contact dermatitis (ACD). OBJECTIVE: To examine trends, associations, and clinical relevance of ACD in patients referred for patch testing who had a final SD diagnosis. METHODS: Retrospective analysis from 2001 to 2016 of 38,723 patients from the North American Contact Dermatitis Group. RESULTS: After patch testing, 303 (0.7%) patients were diagnosed with SD; 46.7% had a concomitant diagnosis of ACD. Patients with vs. without a final SD diagnosis had similar proportions of ≥ 1 positive allergic reaction (59.7% vs. 64.7%; Chi-square, P = 0.0724) but higher odds of allergic reactions to fragrance mix I, bacitracin, quaternium-15, Myroxylon pereirae, benzalkonium chloride, ethyleneurea melamine formaldehyde, diazolidinyl urea, and propylene glycol. The most commonly relevant allergens in patients with final SD diagnosis were fragrance mix I, Myroxylon pereirae, bacitracin, quaternium-15, and formaldehyde. The most common allergen sources were personal care products, topical medications and other health aid products. CONCLUSION: Nearly half of patients with a final SD diagnosis were also diagnosed with ACD, supporting the role of patch testing in select SD patients.
Authors: Melanie D Pratt; Donald V Belsito; Vincent A DeLeo; Joseph F Fowler; Anthony F Fransway; Howard I Maibach; James G Marks; C G Toby Mathias; Robert L Rietschel; Denis Sasseville; Elizabeth F Sherertz; Frances J Storrs; James S Taylor; Kathryn Zug Journal: Dermatitis Date: 2004-12 Impact factor: 4.845