Lauren A Gimbel1, Nathan R Blue1, Amanda A Allshouse1, Robert M Silver1, Bruce Gimbel2, William A Grobman3, David M Haas4, Hyagriv N Simhan5, Brian M Mercer6, Tamera Hatfield7. 1. Obstetrics and Gynecology, University of Utah Health, Salt Lake City, UT, USA. 2. Psychiatry, Saint Mary Mercy Hospital, Livonia, MI, USA. 3. Obstetrics and Gynecology, Northwestern University, Evanston, IL, USA. 4. Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, USA. 5. Obstetrics and Gynecology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. 6. Obstetrics and Gynecology, MetroHealth Medical Center, Cleveland, OH, USA. 7. Obstetrics and Gynecology, University of California Irvine College of Health Sciences, Irvine, CA, USA.
Abstract
OBJECTIVE: To examine pregnancy outcomes in women with treated and untreated anxiety in a well-characterized cohort. STUDY DESIGN: Secondary analysis of the NuMoM2b study, a prospective multi-center cohort of nulliparous women. Anxiety was assessed at 6 weeks 0 days - 13 weeks 6 days using the State Trait Anxiety Inventory (STAI-T). Women were divided into three groups: anxiety and medical treatment, anxiety and no medical treatment, and no anxiety (controls). The primary outcome was a composite of preterm birth, small for gestational age infant, placental abruption (clinically diagnosed), and hypertensive disorders of pregnancy. Multivariable logistic regression was used to adjust for potential confounding variables. RESULTS: Among 8293 eligible women, 24% (n = 1983) had anxiety; 311 were treated medically. The composite outcome (preterm birth, small for gestational age infant, placental abruption, hypertensive disorders of pregnancy) occurred more often in women with untreated anxiety than controls (28.6% vs 25.9%, p=.02), with no difference between treated anxiety and controls (27.7% vs 25.9%, p=.49). After adjustment for confounders, including controlling for depression, there were no differences in the primary outcome among groups. Untreated anxiety remained associated with increased odds of neonatal intensive care unit admission. CONCLUSION: Anxiety occurred in almost a quarter of nulliparas. There was no association between treated or untreated anxiety and our primary outcome of adverse pregnancy outcomes after adjustment for confounders. However, neonates born to women with untreated anxiety were at increased risk for NICU admission.
OBJECTIVE: To examine pregnancy outcomes in women with treated and untreated anxiety in a well-characterized cohort. STUDY DESIGN: Secondary analysis of the NuMoM2b study, a prospective multi-center cohort of nulliparous women. Anxiety was assessed at 6 weeks 0 days - 13 weeks 6 days using the State Trait Anxiety Inventory (STAI-T). Women were divided into three groups: anxiety and medical treatment, anxiety and no medical treatment, and no anxiety (controls). The primary outcome was a composite of preterm birth, small for gestational age infant, placental abruption (clinically diagnosed), and hypertensive disorders of pregnancy. Multivariable logistic regression was used to adjust for potential confounding variables. RESULTS: Among 8293 eligible women, 24% (n = 1983) had anxiety; 311 were treated medically. The composite outcome (preterm birth, small for gestational age infant, placental abruption, hypertensive disorders of pregnancy) occurred more often in women with untreated anxiety than controls (28.6% vs 25.9%, p=.02), with no difference between treated anxiety and controls (27.7% vs 25.9%, p=.49). After adjustment for confounders, including controlling for depression, there were no differences in the primary outcome among groups. Untreated anxiety remained associated with increased odds of neonatal intensive care unit admission. CONCLUSION: Anxiety occurred in almost a quarter of nulliparas. There was no association between treated or untreated anxiety and our primary outcome of adverse pregnancy outcomes after adjustment for confounders. However, neonates born to women with untreated anxiety were at increased risk for NICU admission.
Authors: David M Haas; Derek J Marsh; Danny T Dang; Corette B Parker; Deborah A Wing; Hyagriv N Simhan; William A Grobman; Brian M Mercer; Robert M Silver; Matthew K Hoffman; Samuel Parry; Jay D Iams; Steve N Caritis; Ronald J Wapner; M Sean Esplin; Michal A Elovitz; Alan M Peaceman; Judith Chung; George R Saade; Uma M Reddy Journal: Obstet Gynecol Date: 2018-05 Impact factor: 7.661
Authors: Anja C Huizink; Pascale G Robles de Medina; Eduard J H Mulder; Gerard H A Visser; Jan K Buitelaar Journal: J Child Psychol Psychiatry Date: 2003-09 Impact factor: 8.982