Supriya Arora1, Dmitrii S Maltsev2, Sumit Singh Randhir3, Niroj Kumar Sahoo4, Mahima Jhingan3, Deepika Parmeshwarappa5, Tarun Arora1, Alexei Kulikov2, Claudio Iovino6, Dinah Zur7, Gilad Fainberg7, Mohammed Nasar Ibrahim8, Filippo Tatti6, Ramkailash Gujar9, Ramesh Venkatesh10, Nikitha Reddy10, Ram Snehith10, Enrico Peiretti6, Marco Lupidi9, Jay Chhablani11. 1. Bahamas Vision Center and Princess Margaret Hospital, Nassau, NP, Bahamas. 2. Department of Ophthalmology, Military Medical Academy, St. Petersburg, Russian Federation. 3. Jacobs Retina Center, Shiley Eye Center, University of California, San Diego, USA. 4. Department of Retina and Vitreous, L V Prasad Eye Institute, Vijayawada, India. 5. Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad, India. 6. Department of Surgical Sciences, Eye Clinic, 3111University of Cagliari, Cagliari, Italy. 7. Division of Ophthalmology, 26738Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 8. Department of Electrical Engineering, Indian Institute of Technology, Hyderabad, India. 9. Department of Surgical and Biomedical Sciences, Section of Ophthalmology, 60250University of Perugia, Italy. 10. Department of Retina and Vitreous, 80219Narayana Nethralaya, Bengaluru, India. 11. UPMC Eye Center, 6595University of Pittsburgh, Pittsburgh, USA.
Abstract
PURPOSE: To evaluate the follow up and treatment outcome of central serous chorioretinopathy (CSCR) based on the new multimodal imaging-based classification and identify the predictors for anatomic and visual outcome. METHODS: Retrospective, multicentric study on 95 eyes diagnosed with CSCR and a follow up of at least 12 months were included. Eyes with macular neovascularization, atypical CSCR or any other disease were excluded. RESULTS: At the baseline, observation was advised to 70% eyes with simple CSCR whereas photodynamic therapy (PDT) was performed in 49% eyes with complex CSCR. Over the follow up, decrease in CMT was significantly higher in simple CSCR as compared to complex CSCR (P = 0.008) and the recurrences were significantly more in eyes with lower CMT at baseline (P = 0.0002). Median time of resolution of SRF was 3 months and 6 months in simple and complex CSCR respectively (P = 0.09). For the 12 months follow up, the median fluid free period was greater (P = 0.03) while number of interventions performed was lesser in eyes with simple CSCR as compared to complex CSCR (P = 0.006). Multiple regression analysis showed baseline best corrected visual acuity (BCVA) and baseline persistent SRF to be significantly predictive of BCVA and persistent SRF at 12 months (P < 0.0001, 0.04) respectively. CONCLUSIONS: Complex CSCR more often required PDT, was associated with shorter fluid free interval and longer time for SRF resolution. Baseline BCVA and persistent SRF were predictive of final visual and anatomical outcome. The new multimodal imaging based classification is helpful in establishing objective criteria for planning treatment approaches for CSCR.
PURPOSE: To evaluate the follow up and treatment outcome of central serous chorioretinopathy (CSCR) based on the new multimodal imaging-based classification and identify the predictors for anatomic and visual outcome. METHODS: Retrospective, multicentric study on 95 eyes diagnosed with CSCR and a follow up of at least 12 months were included. Eyes with macular neovascularization, atypical CSCR or any other disease were excluded. RESULTS: At the baseline, observation was advised to 70% eyes with simple CSCR whereas photodynamic therapy (PDT) was performed in 49% eyes with complex CSCR. Over the follow up, decrease in CMT was significantly higher in simple CSCR as compared to complex CSCR (P = 0.008) and the recurrences were significantly more in eyes with lower CMT at baseline (P = 0.0002). Median time of resolution of SRF was 3 months and 6 months in simple and complex CSCR respectively (P = 0.09). For the 12 months follow up, the median fluid free period was greater (P = 0.03) while number of interventions performed was lesser in eyes with simple CSCR as compared to complex CSCR (P = 0.006). Multiple regression analysis showed baseline best corrected visual acuity (BCVA) and baseline persistent SRF to be significantly predictive of BCVA and persistent SRF at 12 months (P < 0.0001, 0.04) respectively. CONCLUSIONS: Complex CSCR more often required PDT, was associated with shorter fluid free interval and longer time for SRF resolution. Baseline BCVA and persistent SRF were predictive of final visual and anatomical outcome. The new multimodal imaging based classification is helpful in establishing objective criteria for planning treatment approaches for CSCR.
Entities:
Keywords:
CME < retina; central serous chorioretinopathy < retina; retina – medical therapies < retina; retinal pathology/research < retina; techniques of retinal examination < retina