Literature DB >> 34746683

Sequenced Breakpoints of Crossover Suppressor/Inversion qC1.

Mark L Edgley1, Stephane Flibotte2, Donald G Moerman1.   

Abstract

We used whole-genome sequencing (WGS) data from a number of balanced lethal strains in Caenorhabditis elegans to show that the crossover suppressor qC1 is an inversion. The rearrangement is complex, with a large primary inversion that contains several other smaller inverted regions. The graphical representation below depicts these various qC1 rearrangements for ease of conceptualization. It is the simplest chromosomal structure compatible with the data currently available, but even then it is worth noting that the complexity of the qC1 chromosome can make the graphical reconstruction difficult to understand, and it may seem a bit like relativity theory or artwork from M.C. Escher (https://moa.byu.edu/m-c-eschers-relativity/). Copyright:
© 2021 by the authors.

Entities:  

Year:  2021        PMID: 34746683      PMCID: PMC8567092          DOI: 10.17912/micropub.biology.000494

Source DB:  PubMed          Journal:  MicroPubl Biol        ISSN: 2578-9430


  7 in total

1.  LG II balancer chromosomes in Caenorhabditis elegans: mT1(II;III) and the mIn1 set of dominantly and recessively marked inversions.

Authors:  M L Edgley; D L Riddle
Journal:  Mol Genet Genomics       Date:  2001-11       Impact factor: 3.291

2.  The meiotic behavior of an inversion in Caenorhabditis elegans.

Authors:  M C Zetka; A M Rose
Journal:  Genetics       Date:  1992-06       Impact factor: 4.562

3.  Transcript analysis of glp-1 and lin-12, homologous genes required for cell interactions during development of C. elegans.

Authors:  J Austin; J Kimble
Journal:  Cell       Date:  1989-08-11       Impact factor: 41.582

Review 4.  Genetic balancers.

Authors:  M L Edgley; D L Baillie; D L Riddle; A M Rose
Journal:  Methods Cell Biol       Date:  1995       Impact factor: 1.441

5.  Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration.

Authors:  Helga Thorvaldsdóttir; James T Robinson; Jill P Mesirov
Journal:  Brief Bioinform       Date:  2012-04-19       Impact factor: 11.622

6.  Identification of essential genes in Caenorhabditis elegans through whole-genome sequencing of legacy mutant collections.

Authors:  Erica Li-Leger; Richard Feichtinger; Stephane Flibotte; Heinke Holzkamp; Ralf Schnabel; Donald G Moerman
Journal:  G3 (Bethesda)       Date:  2021-12-08       Impact factor: 3.154

7.  LUMPY: a probabilistic framework for structural variant discovery.

Authors:  Ryan M Layer; Colby Chiang; Aaron R Quinlan; Ira M Hall
Journal:  Genome Biol       Date:  2014-06-26       Impact factor: 13.583

  7 in total

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