Martin de la Presa1,2, Amit Govil2, Winston D Chamberlain3, Edward J Holland1,2. 1. Cornea Department, Cincinnati Eye Institute, Cincinnati, OH. 2. Department of Ophthalmology, University of Cincinnati, Cincinnati, OH; and. 3. Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR.
Abstract
PURPOSE: The purpose of this study was to report a case of acute corneal epithelial rejection of living-related conjunctival limbal allograft (LR-CLAL) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. OBSERVATIONS: A 27-year-old woman developed acute epithelial rejection of LR-CLAL 2 weeks after receiving the SARS-CoV-2 vaccine. She received the LR-CLAL transplant 4 years and 7 months previously and had a stable clinical course with no history of rejection. She had an ABO blood group and human leukocyte antigen compatible donor, no systemic comorbidities, and no rejection risk factors. CONCLUSIONS: The novel SARS-CoV-2 vaccine upregulates the immune system to produce an adaptive immune response. The SARS-CoV-2 vaccine may potentially be associated with increased risk of rejection in those with ocular surface transplants.
PURPOSE: The purpose of this study was to report a case of acute corneal epithelial rejection of living-related conjunctival limbal allograft (LR-CLAL) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. OBSERVATIONS: A 27-year-old woman developed acute epithelial rejection of LR-CLAL 2 weeks after receiving the SARS-CoV-2 vaccine. She received the LR-CLAL transplant 4 years and 7 months previously and had a stable clinical course with no history of rejection. She had an ABO blood group and human leukocyte antigen compatible donor, no systemic comorbidities, and no rejection risk factors. CONCLUSIONS: The novel SARS-CoV-2 vaccine upregulates the immune system to produce an adaptive immune response. The SARS-CoV-2 vaccine may potentially be associated with increased risk of rejection in those with ocular surface transplants.
Authors: Saad Alhumaid; Ali A Rabaan; Kuldeep Dhama; Shin Jie Yong; Firzan Nainu; Khalid Hajissa; Nourah Al Dossary; Khulood Khaled Alajmi; Afaf E Al Saggar; Fahad Abdullah AlHarbi; Mohammed Buhays Aswany; Abdullah Abdulaziz Alshayee; Saad Abdalaziz Alrabiah; Ahmed Mahmoud Saleh; Mohammed Ali Alqarni; Fahad Mohammed Al Gharib; Shahd Nabeel Qattan; Hassan M Almusabeh; Hussain Yousef AlGhatm; Sameer Ahmed Almoraihel; Ahmed Saeed Alzuwaid; Mohammed Ali Albaqshi; Murtadha Ahmed Al Khalaf; Yasmine Ahmed Albaqshi; Abdulsatar H Al Brahim; Mahdi Mana Al Mutared; Hassan Al-Helal; Header A Alghazal; Abbas Al Mutair Journal: Vaccines (Basel) Date: 2022-08-10