Yaqin Wang1, Xiaoling Zhu1, Zhiheng Chen1, Pingting Yang1, Lei Liu1, Xuelian Liu1, Liuxin Wu2, Qingnan He1, Ying Li3. 1. Health Management Center, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China; Health Management Research Center of Central South University, Changsha, 410013, Hunan, China. 2. Health Management Research Center of Central South University, Changsha, 410013, Hunan, China. 3. Health Management Center, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China; Health Management Research Center of Central South University, Changsha, 410013, Hunan, China. Electronic address: 37618190@qq.com.
Abstract
PURPOSE: The prognostic significance of obesity phenotypes is under debate, and few studies have characterized their transition trajectories. This study examined the natural courses of different phenotypes and their associations with cardiovascular disease risks. METHODS: A total of 1827 participants were followed for 14 years and re-evaluated every 4-5 years. Four metabolite BMI phenotypes were determined according to overweight or obesity (BMI ≥ 24 kg/m2) and metabolic health status (≤1 Adult Treatment Panel III criteria, excluding waist circumference). Cardiovascular risks were assessed by evaluating baPWV and hypertension, diabetes and chronic kidney disease (CKD) development. RESULTS: More than 20% of participants changed their initial phenotypes within 5 years. One-third of healthy overweight/obese (MHO) individuals became unhealthy, and only 10.6% regressed to a healthy normal weight (MHN) at the end of follow-up. Compared with MHN participants, MHO participants had higher odds of increased baPWV (OR: 1.18, 95% CI, 0.42-3.33) and increased risks of incident hypertension (HR: 1.87, 95% CI, 1.18-2.98) and diabetes (HR: 2.61, 95% CI, 1.35-5.03). Metabolic deterioration during follow-up resulted in an increased risk of baPWV and clinical diseases. CONCLUSIONS: The natural trajectory of metabolite BMI phenotypes is time-varying, and interventions for both healthy and unhealthy overweight/obese individuals should be widely recommended.
PURPOSE: The prognostic significance of obesity phenotypes is under debate, and few studies have characterized their transition trajectories. This study examined the natural courses of different phenotypes and their associations with cardiovascular disease risks. METHODS: A total of 1827 participants were followed for 14 years and re-evaluated every 4-5 years. Four metabolite BMI phenotypes were determined according to overweight or obesity (BMI ≥ 24 kg/m2) and metabolic health status (≤1 Adult Treatment Panel III criteria, excluding waist circumference). Cardiovascular risks were assessed by evaluating baPWV and hypertension, diabetes and chronic kidney disease (CKD) development. RESULTS: More than 20% of participants changed their initial phenotypes within 5 years. One-third of healthy overweight/obese (MHO) individuals became unhealthy, and only 10.6% regressed to a healthy normal weight (MHN) at the end of follow-up. Compared with MHN participants, MHO participants had higher odds of increased baPWV (OR: 1.18, 95% CI, 0.42-3.33) and increased risks of incident hypertension (HR: 1.87, 95% CI, 1.18-2.98) and diabetes (HR: 2.61, 95% CI, 1.35-5.03). Metabolic deterioration during follow-up resulted in an increased risk of baPWV and clinical diseases. CONCLUSIONS: The natural trajectory of metabolite BMI phenotypes is time-varying, and interventions for both healthy and unhealthy overweight/obese individuals should be widely recommended.
Authors: Victor M Oguoma; Mohamed Abu-Farha; Neil T Coffee; Saad Alsharrah; Faisal H Al-Refaei; Jehad Abubaker; Mark Daniel; Fahd Al-Mulla Journal: Nutrients Date: 2022-02-22 Impact factor: 5.717