Mousareza Anbarlouei1,2, Maziar Emamikhah1,3, Kamal Basiri4, Gholamreza Farzanegan5,6. 1. Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. 2. Department of Neurosurgery, Baqiyatallah University of Medical Sciences, Tehran, Iran. 3. Rasoul Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. 4. Department of Emergency Medicine, Prehospital and Hospital Emergency Research Center, Tehran University of Medical Sciences, Tehran, Iran. 5. Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. drrezafarzanegan44@gmail.com. 6. Department of Neurosurgery, Baqiyatallah University of Medical Sciences, Tehran, Iran. drrezafarzanegan44@gmail.com.
Abstract
BACKGROUND: The contributing risk factors in development of seizure after supratentorial craniotomy, the optimal duration of prophylactic antiepileptic therapy, the high-risk patient to treat, and the drug of choice are subjects of debate as is the gold standard diagnostic tool for patient screening. Combining routine electroencephalography (EEG) with clinical data to identify high-risk patients and determine the ideal time of recording after surgery was the goal of this study. METHODS: In this prospective cohort, 59 patients were evaluated with three EEG recordings after different intervals of supratentorial craniotomy due to different etiologies and were followed for 9 months for development of seizures. Demographic and disease-related variables as well as EEG results were analyzed to determine the contributing risk factors for development of seizures. RESULTS: Neoplastic etiology and abnormal perioperative EEG (performed before surgery or in the first postoperative week) were the only independent variables associated with development of de novo seizure. CONCLUSION: Routine EEG in the perioperative period and neoplastic etiology are two independent powerful predictors of developing seizure after supratentorial craniotomy and may help deciding whether to continue prophylactic antiepileptic medications for an extended period or not.
BACKGROUND: The contributing risk factors in development of seizure after supratentorial craniotomy, the optimal duration of prophylactic antiepileptic therapy, the high-risk patient to treat, and the drug of choice are subjects of debate as is the gold standard diagnostic tool for patient screening. Combining routine electroencephalography (EEG) with clinical data to identify high-risk patients and determine the ideal time of recording after surgery was the goal of this study. METHODS: In this prospective cohort, 59 patients were evaluated with three EEG recordings after different intervals of supratentorial craniotomy due to different etiologies and were followed for 9 months for development of seizures. Demographic and disease-related variables as well as EEG results were analyzed to determine the contributing risk factors for development of seizures. RESULTS: Neoplastic etiology and abnormal perioperative EEG (performed before surgery or in the first postoperative week) were the only independent variables associated with development of de novo seizure. CONCLUSION: Routine EEG in the perioperative period and neoplastic etiology are two independent powerful predictors of developing seizure after supratentorial craniotomy and may help deciding whether to continue prophylactic antiepileptic medications for an extended period or not.