Literature DB >> 34741167

Immune and non-immune functions of adipose tissue leukocytes.

W V Trim1,2, L Lynch3,4.   

Abstract

Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence. Much of the work into understanding the role of immune cells in adipose tissue has been in the context of obesity. These investigations have also uncovered a range of typical (immune) and non-typical functions exerted by adipose tissue leukocytes. Here we provide an overview of the adipose tissue immune system, including its role as an immune reservoir in the whole-body response to infection and as a site of parasitic and viral infections. We also describe the functional roles of specialized immunological structures found within adipose tissue. However, our main focus is on the recently discovered 'non-immune' functions of adipose tissue immune cells, which include the regulation of adipocyte homeostasis, as well as responses to changing nutrient status and body temperature. In doing so, we outline the therapeutic potential of the adipose tissue immune system in health and disease.
© 2021. Springer Nature Limited.

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Year:  2021        PMID： 34741167     DOI： 10.1038/s41577-021-00635-7

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   108.555


  192 in total

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9.  Health Effects of Overweight and Obesity in 195 Countries over 25 Years.

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Journal:  N Engl J Med       Date:  2017-06-12       Impact factor: 91.245

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Authors:  William Trim; James E Turner; Dylan Thompson
Journal:  Front Immunol       Date:  2018-02-09       Impact factor: 7.561
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Authors:  Anna Zawistowska-Deniziak; Joost M Lambooij; Alicja Kalinowska; Thiago A Patente; Maciej Łapiński; Hendrik J P van der Zande; Katarzyna Basałaj; Clarize M de Korne; Mathilde A M Chayé; Thomas A Gasan; Luke J Norbury; Martin Giera; Arnaud Zaldumbide; Hermelijn H Smits; Bruno Guigas
Journal:  Front Immunol       Date:  2022-05-26       Impact factor: 8.786

Review 3.  Role of Innate lymphoid Cells in Obesity and Insulin Resistance.

Authors:  Hong Chen; Lijun Sun; Lu Feng; Yue Yin; Weizhen Zhang
Journal:  Front Endocrinol (Lausanne)       Date:  2022-04-27       Impact factor: 6.055

Review 4.  Obesity and the Brain.

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Journal:  Int J Mol Sci       Date:  2022-05-30       Impact factor: 6.208

Review 5.  The shades of grey in adipose tissue reprogramming.

Authors:  Yue Qi; Xiaoyan Hui
Journal:  Biosci Rep       Date:  2022-03-31       Impact factor: 3.840

Review 6.  Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology.

Authors:  Simon Lecoutre; Mélanie Lambert; Krzysztof Drygalski; Isabelle Dugail; Salwan Maqdasy; Mathieu Hautefeuille; Karine Clément
Journal:  Cells       Date:  2022-07-27       Impact factor: 7.666
  6 in total

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