Pitchai Balakumar1, Gowraganahalli Jagadeesh2. 1. Department of Pharmacology, Pannai College of Pharmacy, Dindigul 624005, India. Electronic address: pbala2006@gmail.com. 2. Division of Pharmacology & Toxicology, Office of Cardiology, Hematology, Endocrinology, and Nephrology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA. Electronic address: Gowra.Jagadeesh@fda.hhs.gov.