| Literature DB >> 3473891 |
A Skottner, L Fryklund, H A Hansson.
Abstract
IGF-1 has been produced by recombinant DNA technology; the host cell is a yeast. Studies in hypophysectomized rats show that IGF-1 has little growth promoting effect unless given by infusion at high doses, and priming with bovine growth hormone did not produce any potentiation. In vitro studies reveal that IGF-1 cross-reacts with the insulin receptor on adipose cells. Immunohistochemical studies have revealed high IGF-1 immunoreactivity in proliferating and differentiating cells in the testes, lymphoid organs and pancreatic islets and particularly in regenerating nerves. Local application of IGF-1 may stimulate regeneration in damaged peripheral nerves. Key words:Entities:
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Year: 1986 PMID： 3473891 DOI： 10.1111/j.1651-2227.1986.tb10376.x
Source DB: PubMed Journal: Acta Paediatr Scand Suppl ISSN： 0300-8843