| Literature DB >> 34735226 |
Zehan Hu1,2, Chenlu Zhang3, Luis Sifuentes-Dominguez4, Christina M Zarek1, Daniel C Propheter1, Zheng Kuang1, Yuhao Wang1, Mihir Pendse1, Kelly A Ruhn1, Brian Hassell1, Cassie L Behrendt1, Bo Zhang1, Prithvi Raj1, Tamia A Harris-Tryon3, Tiffany A Reese1, Lora V Hooper1,2.
Abstract
A diverse group of antimicrobial proteins (AMPs) helps protect the mammalian intestine from varied microbial challenges. We show that small proline-rich protein 2A (SPRR2A) is an intestinal antibacterial protein that is phylogenetically unrelated to previously discovered mammalian AMPs. In this study, SPRR2A was expressed in Paneth cells and goblet cells and selectively killed Gram-positive bacteria by disrupting their membranes. SPRR2A shaped intestinal microbiota composition, restricted bacterial association with the intestinal surface, and protected against Listeria monocytogenes infection. SPRR2A differed from other intestinal AMPs in that it was induced by type 2 cytokines produced during helminth infection. Moreover, SPRR2A protected against helminth-induced bacterial invasion of intestinal tissue. Thus, SPRR2A is a distinctive AMP triggered by type 2 immunity that protects the intestinal barrier during helminth infection.Entities:
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Year: 2021 PMID： 34735226 PMCID： PMC8977106 DOI： 10.1126/science.abe6723
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728