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Literature DB >> 34732854

Degrading disease-causing RNA in ALS.

Megan Cully.

Abstract

Entities: Chemical

Mesh：

Substances：
Ribonucleases

Year: 2021 PMID： 34732854 DOI： 10.1038/d41573-021-00189-2

Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694

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1 in total

1. Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G₄C₂) repeat expansion in vitro and in vivo ALS models.

Authors: Jessica A Bush; Haruo Aikawa; Rita Fuerst; Yue Li; Andrei Ursu; Samantha M Meyer; Raphael I Benhamou; Jonathan L Chen; Tanya Khan; Sarah Wagner-Griffin; Montina J Van Meter; Yuquan Tong; Hailey Olafson; Kendra K McKee; Jessica L Childs-Disney; Tania F Gendron; Yongjie Zhang; Alyssa N Coyne; Eric T Wang; Ilyas Yildirim; Kye Won Wang; Leonard Petrucelli; Jeffrey D Rothstein; Matthew D Disney
Journal: Sci Transl Med Date: 2021-10-27 Impact factor: 19.319

1 in total

Degrading disease-causing RNA in ALS.

1. Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models.

1. Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G₄C₂) repeat expansion in vitro and in vivo ALS models.