BACKGROUND: Outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) among patients with peritoneal carcinomatosis (PC) depend largely on the extent of peritoneal disease. Since PC is not reliably evaluated with cross-sectional imaging, tumor burden is often evaluated with diagnostic laparoscopy (DLS). The aims of this study are to evaluate the safety of DLS in patients with peritoneal disease and determine if DLS delays time to CRS-HIPEC. METHODS: We performed an institutional retrospective review of 145 patients who underwent CRS-HIPEC between 2013 and 2020. Patients were divided into 2 groups: those who underwent an electively scheduled DLS prior to CRS-HIPEC and those who did not. Intraoperative and postoperative complications associated with DLS were determined from the surgeon's operative report. Time from diagnosis of PC to CRS-HIPEC was compared between the 2 groups. RESULTS: Of the 145 patients available for analysis, 47% (68) underwent DLS and 44% (64) did not. Of all the diagnostic laparoscopies performed, there was 1 (1.5%) intraoperative complication. The duration between diagnosis of peritoneal carcinomatosis and surgery was 4.9 months among patients who underwent DLS prior to CRS-HIPEC and 4.3 months among patients who did not (P = .79). CONCLUSION: In this retrospective analysis, diagnostic laparoscopy prior to CRS-HIPEC demonstrated a comparable rate of DLS-associated complications compared to other gastrointestinal malignancies and does not prolong time from diagnosis to CRS-HIPEC. Thus, in patients undergoing evaluation for CRS-HIPEC, diagnostic laparoscopy provides significant value in patient selection without incurring perioperative risk or delay in CRS-HIPEC.
BACKGROUND: Outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) among patients with peritoneal carcinomatosis (PC) depend largely on the extent of peritoneal disease. Since PC is not reliably evaluated with cross-sectional imaging, tumor burden is often evaluated with diagnostic laparoscopy (DLS). The aims of this study are to evaluate the safety of DLS in patients with peritoneal disease and determine if DLS delays time to CRS-HIPEC. METHODS: We performed an institutional retrospective review of 145 patients who underwent CRS-HIPEC between 2013 and 2020. Patients were divided into 2 groups: those who underwent an electively scheduled DLS prior to CRS-HIPEC and those who did not. Intraoperative and postoperative complications associated with DLS were determined from the surgeon's operative report. Time from diagnosis of PC to CRS-HIPEC was compared between the 2 groups. RESULTS: Of the 145 patients available for analysis, 47% (68) underwent DLS and 44% (64) did not. Of all the diagnostic laparoscopies performed, there was 1 (1.5%) intraoperative complication. The duration between diagnosis of peritoneal carcinomatosis and surgery was 4.9 months among patients who underwent DLS prior to CRS-HIPEC and 4.3 months among patients who did not (P = .79). CONCLUSION: In this retrospective analysis, diagnostic laparoscopy prior to CRS-HIPEC demonstrated a comparable rate of DLS-associated complications compared to other gastrointestinal malignancies and does not prolong time from diagnosis to CRS-HIPEC. Thus, in patients undergoing evaluation for CRS-HIPEC, diagnostic laparoscopy provides significant value in patient selection without incurring perioperative risk or delay in CRS-HIPEC.
Entities:
Keywords:
cytoreductive surgery with hyperthermic intraperitoneal chemotherapy; diagnostic laparoscopy; hyperthermic intraperitoneal chemotherapy; peritoneal carcinomatosis; surgical oncology
Authors: Parissa Tabrizian; Thejus T Jayakrishnan; Anthony Zacharias; Samantha Aycart; Fabian M Johnston; Umut Sarpel; Daniel M Labow; Kiran K Turaga Journal: J Surg Oncol Date: 2015-06-03 Impact factor: 3.454
Authors: Paul J Karanicolas; Elena B Elkin; Lindsay M Jacks; Coral L Atoria; Vivian E Strong; Murray F Brennan; Daniel G Coit Journal: J Am Coll Surg Date: 2011-08-26 Impact factor: 6.113
Authors: Gary V Walker; Stephen R Grant; B Ashleigh Guadagnolo; Karen E Hoffman; Benjamin D Smith; Matthew Koshy; Pamela K Allen; Usama Mahmood Journal: J Clin Oncol Date: 2014-08-04 Impact factor: 44.544
Authors: Thomas Schnelldorfer; Andrew I Gagnon; Richard T Birkett; Gail Reynolds; Kristen M Murphy; Roger L Jenkins Journal: J Am Coll Surg Date: 2014-02-28 Impact factor: 6.113
Authors: Judith E K R Hentzen; Willemijn Y van der Plas; Lukas B Been; Frederik J H Hoogwater; Robert J van Ginkel; Gooitzen M van Dam; Patrick H J Hemmer; Schelto Kruijff Journal: Ann Surg Oncol Date: 2020-02-12 Impact factor: 5.344
Authors: J E K R Hentzen; W Y van der Plas; R D N Constansia; L B Been; F J H Hoogwater; R J van Ginkel; G M van Dam; P H J Hemmer; S Kruijff Journal: BJS Open Date: 2019-09-18