| Literature DB >> 34725462 |
Xianjie Jiang1,2, Xiangying Deng2, Jie Wang2, Yongzhen Mo2, Lei Shi2,3, Fang Wei2, Shanshan Zhang4, Zhaojian Gong3, Yi He1, Fang Xiong4, Yumin Wang2, Can Guo2, Bo Xiang1,2, Ming Zhou1,2, Qianjin Liao1, Xiaoling Li1,2, Yong Li5, Guiyuan Li1,2, Wei Xiong1,2, Zhaoyang Zeng6,7.
Abstract
Nasopharyngeal carcinoma (NPC) demonstrates significant regional differences and a high incidence in Southeast Asia and Southern China. Bactericidal/permeability-increasing-fold- containing family B member 1 (BPIFB1) is a relatively specific and highly expressed protein in the nasopharyngeal epithelium. BPIFB1 expression is substantially downregulated in NPC and is significantly associated with poor prognosis in patients with NPC. However, the specific molecular mechanism by which BPIFB1 regulates NPC is not well understood. In this study, we found that BPIFB1 inhibits vasculogenic mimicry by regulating the metabolic reprogramming of NPC. BPIFB1 decreases GLUT1 transcription by downregulating the JNK/AP1 signaling pathway. Altered glycolysis reduces the acetylation level of histone and decreases the expression of vasculogenic mimicry-related genes, VEGFA, VE-cadherin, and MMP2, ultimately leading to the inhibition of vasculogenic mimicry. To our knowledge, this is the first report on the role and specific mechanism of BPIFB1 as a tumor suppressor gene involved in regulating glycolysis and vasculogenic mimicry in NPC. Overall, these results provide a new therapeutic target for NPC diagnosis and treatment.Entities:
Mesh：
Substances：
Year: 2021 PMID： 34725462 DOI： 10.1038/s41388-021-02079-8
Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867