Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A Mosquito AgTRIO Monoclonal Antibody Reduces Early Plasmodium Infection of Mice.

Literature DB >> 34724388

A Mosquito AgTRIO Monoclonal Antibody Reduces Early Plasmodium Infection of Mice.

Yu-Min Chuang¹, Xu-Dong Tang², Erol Fikrig¹.

Abstract

Malaria begins when an infected mosquito injects saliva containing Plasmodium sporozoites into the skin of a vertebrate host. Passive immunization of mice with antiserum against the Anopheles gambiae mosquito saliva protein TRIO (AgTRIO) offers significant protection against Plasmodium infection of mice. Furthermore, passive transfer of both AgTRIO antiserum and an anti-circumsporozoite protein monoclonal antibody provides synergistic protection. In this study, we generated monoclonal antibodies against AgTRIO to delineate the regions of AgTRIO associated with protective immunity. Monoclonal antibody 13F-1 markedly reduced Plasmodium infection in mice and recognized a region (VDDLMAKFN) in the carboxyl terminus of AgTRIO. 13F-1 is an IgG2a isotype monoclonal antibody, and the Fc region is required for protection. These data will aid in the generation of future malaria vaccines that may include both pathogen and vector antigens.

Entities: Chemical

Keywords: AgTRIO; Plasmodium; malaria; monoclonal antibodies; mosquito saliva protein

Mesh：

Substances：

Year: 2021 PMID： 34724388 PMCID： PMC8788779 DOI： 10.1128/IAI.00359-21

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.609

Keyword Cloud
References

24 in total

1. First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children.

Authors: Selidji Todagbe Agnandji; Bertrand Lell; Solange Solmeheim Soulanoudjingar; José Francisco Fernandes; Béatrice Peggy Abossolo; Cornelia Conzelmann; Barbara Gaelle Nfono Ondo Methogo; Yannick Doucka; Arnaud Flamen; Benjamin Mordmüller; Saadou Issifou; Peter Gottfried Kremsner; Jahit Sacarlal; Pedro Aide; Miguel Lanaspa; John J Aponte; Arlindo Nhamuave; Diana Quelhas; Quique Bassat; Sofia Mandjate; Eusébio Macete; Pedro Alonso; Salim Abdulla; Nahya Salim; Omar Juma; Mwanajaa Shomari; Kafuruki Shubis; Francisca Machera; Ali Said Hamad; Rose Minja; Ali Mtoro; Alma Sykes; Saumu Ahmed; Alwisa Martin Urassa; Ali Mohammed Ali; Grace Mwangoka; Marcel Tanner; Halidou Tinto; Umberto D'Alessandro; Hermann Sorgho; Innocent Valea; Marc Christian Tahita; William Kaboré; Sayouba Ouédraogo; Yara Sandrine; Robert Tinga Guiguemdé; Jean Bosco Ouédraogo; Mary J Hamel; Simon Kariuki; Chris Odero; Martina Oneko; Kephas Otieno; Norbert Awino; Jackton Omoto; John Williamson; Vincent Muturi-Kioi; Kayla F Laserson; Laurence Slutsker; Walter Otieno; Lucas Otieno; Otsyula Nekoye; Stacey Gondi; Allan Otieno; Bernhards Ogutu; Ruth Wasuna; Victorine Owira; David Jones; Agnes Akoth Onyango; Patricia Njuguna; Roma Chilengi; Pauline Akoo; Christine Kerubo; Jesse Gitaka; Charity Maingi; Trudie Lang; Ally Olotu; Benjamin Tsofa; Philip Bejon; Norbert Peshu; Kevin Marsh; Seth Owusu-Agyei; Kwaku Poku Asante; Kingsley Osei-Kwakye; Owusu Boahen; Samuel Ayamba; Kingsley Kayan; Ruth Owusu-Ofori; David Dosoo; Isaac Asante; George Adjei; George Adjei; Daniel Chandramohan; Brian Greenwood; John Lusingu; Samwel Gesase; Anangisye Malabeja; Omari Abdul; Hassan Kilavo; Coline Mahende; Edwin Liheluka; Martha Lemnge; Thor Theander; Chris Drakeley; Daniel Ansong; Tsiri Agbenyega; Samuel Adjei; Harry Owusu Boateng; Theresa Rettig; John Bawa; Justice Sylverken; David Sambian; Alex Agyekum; Larko Owusu; Francis Martinson; Irving Hoffman; Tisungane Mvalo; Portia Kamthunzi; Ruthendo Nkomo; Albans Msika; Allan Jumbe; Nelecy Chome; Dalitso Nyakuipa; Joseph Chintedza; W Ripley Ballou; Myriam Bruls; Joe Cohen; Yolanda Guerra; Erik Jongert; Didier Lapierre; Amanda Leach; Marc Lievens; Opokua Ofori-Anyinam; Johan Vekemans; Terrell Carter; Didier Leboulleux; Christian Loucq; Afiya Radford; Barbara Savarese; David Schellenberg; Marla Sillman; Preeti Vansadia
Journal: N Engl J Med Date: 2011-10-18 Impact factor: 91.245

Review 2. Humanization of antibodies.

Authors: Juan C Almagro; Johan Fransson
Journal: Front Biosci Date: 2008-01-01

Review 3. Antibody humanization methods - a review and update.

Authors: Yaghoub Safdari; Safar Farajnia; Mohammad Asgharzadeh; Masoumeh Khalili
Journal: Biotechnol Genet Eng Rev Date: 2013-08-02

4. Anopheles gambiae Lacking AgTRIO Inefficiently Transmits Plasmodium berghei to Mice.

Authors: Yu-Min Chuang; Marianna Freudzon; Jing Yang; Yuemei Dong; George Dimopoulos; Erol Fikrig
Journal: Infect Immun Date: 2019-08-21 Impact factor: 3.441

5. IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming.

Authors: Willianne Hoepel; Sona Allahverdiyeva; Haneen Harbiye; Steven W de Taeye; Alwin J van der Ham; Leonie de Boer; Sebastiaan A J Zaat; Michel van Weeghel; Dominique L P Baeten; Riekelt H Houtkooper; Bart Everts; Gestur Vidarsson; Jeroen den Dunnen
Journal: J Immunol Date: 2020-11-13 Impact factor: 5.422

10. Efficacy and safety of the RTS,S/AS01 malaria vaccine during 18 months after vaccination: a phase 3 randomized, controlled trial in children and young infants at 11 African sites.

Authors:
Journal: PLoS Med Date: 2014-07-29 Impact factor: 11.069

A Mosquito AgTRIO Monoclonal Antibody Reduces Early Plasmodium Infection of Mice.

1. First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children.

Review 2. Humanization of antibodies.

Review 3. Antibody humanization methods - a review and update.

4. Anopheles gambiae Lacking AgTRIO Inefficiently Transmits Plasmodium berghei to Mice.

5. IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming.

6. CD8+ T effector memory cells protect against liver-stage malaria.

7. Roles of Fc Domain and Exudation in L2 Antibody-Mediated Protection against Human Papillomavirus.

8. The Effects of A Mosquito Salivary Protein on Sporozoite Traversal of Host Cells.

9. The Role of IgG Subclass in Antibody-Mediated Protection against Carbapenem-Resistant Klebsiella pneumoniae.

10. Efficacy and safety of the RTS,S/AS01 malaria vaccine during 18 months after vaccination: a phase 3 randomized, controlled trial in children and young infants at 11 African sites.