Literature DB >> 34723631

Evaluation of Bacteriophage Cocktails Alone and in Combination with Daptomycin against Daptomycin-Nonsusceptible Enterococcus faecium.

Taylor Morrisette1, Katherine L Lev1, Gregory S Canfield2,3, Breck A Duerkop3, Razieh Kebriaei1, Kyle C Stamper1, Dana Holger1, Susan M Lehman4, Smaranda Willcox5, Cesar A Arias6,7, Michael J Rybak1,8,9.   

Abstract

Enterococcus faecium is a significant multidrug-resistant pathogen. Bacteriophage cocktails are being proposed to complement antibiotic therapy. After a screen of 8 E. faecium strains against 4 phages, 2 phages (113 and 9184) with the broadest host ranges were chosen for further experiments. Transmission electron microscopy, whole-genome sequencing, comparative genome analyses, and time-kill analyses were performed. Daptomycin (DAP) plus the phage cocktail (113 [myophage] and 9184 [siphopage]) showed bactericidal activity in most regimens, while DAP addition prevented phage 9184 resistance against daptomycin-nonsusceptible E. faecium.

Entities:  

Keywords:  Enterococcus faecium; bacteriophage cocktails; bacteriophage-antibiotic combinations; bacteriophages; daptomycin

Mesh：

Substances：

Year:  2021        PMID： 34723631      PMCID： PMC8765229          DOI： 10.1128/AAC.01623-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.938


  24 in total

Review 1.  5500 Phages examined in the electron microscope.

Authors:  H-W Ackermann
Journal:  Arch Virol       Date:  2006-10-19       Impact factor: 2.574

2.  Targeting Enterococcus faecalis biofilms with phage therapy.

Authors:  Leron Khalifa; Yair Brosh; Daniel Gelman; Shunit Coppenhagen-Glazer; Shaul Beyth; Ronit Poradosu-Cohen; Yok-Ai Que; Nurit Beyth; Ronen Hazan
Journal:  Appl Environ Microbiol       Date:  2015-02-06       Impact factor: 4.792

Review 3.  The rise of the Enterococcus: beyond vancomycin resistance.

Authors:  Cesar A Arias; Barbara E Murray
Journal:  Nat Rev Microbiol       Date:  2012-03-16       Impact factor: 60.633

Review 4.  Bacteriophage Therapeutics: A Primer for Clinicians on Phage-Antibiotic Combinations.

Authors:  Taylor Morrisette; Razieh Kebriaei; Katherine L Lev; Sandra Morales; Michael J Rybak
Journal:  Pharmacotherapy       Date:  2020-01-13       Impact factor: 4.705

5.  An Adaptive Mutation in Enterococcus faecium LiaR Associated with Antimicrobial Peptide Resistance Mimics Phosphorylation and Stabilizes LiaR in an Activated State.

Authors:  Milya Davlieva; Angel Tovar-Yanez; Kimberly DeBruler; Paul G Leonard; Michael R Zianni; Cesar A Arias; Yousif Shamoo
Journal:  J Mol Biol       Date:  2016-09-23       Impact factor: 5.469

6.  Influence of Inoculum Effect on the Efficacy of Daptomycin Monotherapy and in Combination with β-Lactams against Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions.

Authors:  Razieh Kebriaei; Seth A Rice; Kavindra V Singh; Kyle C Stamper; An Q Dinh; Rafael Rios; Lorena Diaz; Barbara E Murray; Jose M Munita; Truc T Tran; Cesar A Arias; Michael J Rybak
Journal:  Antimicrob Agents Chemother       Date:  2018-07-27       Impact factor: 5.191

7.  Galaxy and Apollo as a biologist-friendly interface for high-quality cooperative phage genome annotation.

Authors:  Jolene Ramsey; Helena Rasche; Cory Maughmer; Anthony Criscione; Eleni Mijalis; Mei Liu; James C Hu; Ry Young; Jason J Gill
Journal:  PLoS Comput Biol       Date:  2020-11-02       Impact factor: 4.475

Review 8.  Bacteriophage Procurement for Therapeutic Purposes.

Authors:  Beata Weber-Dąbrowska; Ewa Jończyk-Matysiak; Maciej Żaczek; Małgorzata Łobocka; Marzanna Łusiak-Szelachowska; Andrzej Górski
Journal:  Front Microbiol       Date:  2016-08-12       Impact factor: 5.640

9.  A retrospective clinical comparison of daptomycin vs daptomycin and a beta-lactam antibiotic for treating vancomycin-resistant Enterococcus faecium bloodstream infections.

Authors:  Yu-Chung Chuang; Pao-Yu Chen; Chi-Ying Lin; Yee-Chun Chen; Jann-Tay Wang; Shan-Chwen Chang
Journal:  Sci Rep       Date:  2018-01-26       Impact factor: 4.379

10.  Design and Preclinical Development of a Phage Product for the Treatment of Antibiotic-Resistant Staphylococcus aureus Infections.

Authors:  Susan M Lehman; Gillian Mearns; Deborah Rankin; Robert A Cole; Frenk Smrekar; Steven D Branston; Sandra Morales
Journal:  Viruses       Date:  2019-01-21       Impact factor: 5.048
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  3 in total

Review 1.  Bacteriophage Therapy for Critical and High-Priority Antibiotic-Resistant Bacteria and Phage Cocktail-Antibiotic Formulation Perspective.

Authors:  Gursneh Kaur; Ritika Agarwal; Rakesh Kumar Sharma
Journal:  Food Environ Virol       Date:  2021-06-12       Impact factor: 2.778

Review 2.  Bacteriophages and antibiotic interactions in clinical practice: what we have learned so far.

Authors:  Marzanna Łusiak-Szelachowska; Ryszard Międzybrodzki; Zuzanna Drulis-Kawa; Kathryn Cater; Petar Knežević; Cyprian Winogradow; Karolina Amaro; Ewa Jończyk-Matysiak; Beata Weber-Dąbrowska; Justyna Rękas; Andrzej Górski
Journal:  J Biomed Sci       Date:  2022-03-30       Impact factor: 8.410

3.  Phage Cocktails Constrain the Growth of Enterococcus.

Authors:  Stephen Wandro; Pooja Ghatbale; Hedieh Attai; Clark Hendrickson; Cyril Samillano; Joy Suh; Sage J B Dunham; David T Pride; Katrine Whiteson
Journal:  mSystems       Date:  2022-06-28       Impact factor: 7.324
  3 in total

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