Nur Melani Sari1, Regina Hadiputri2, Maya Sari Kuntorini3, Hasrayati Agustina4, Friska Mardianty5. 1. Department of Child Health, Dr. Hasan Sadikin Hospital/Universitas Padjadjaran, Bandung, Indonesia. 2. Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia. 3. Department of Opthalmology, Cicendo National Eye Hospital, Universitas Padjadjaran, Bandung, Indonesia. 4. Department of Anatomic Pathology, Dr. Hasan Sadikin Hospital, Universitas Padjadjaran, Bandung, Indonesia. 5. Anatomic Pathology Laboratory, Cicendo National Eye Hospital, Universitas Padjadjaran, Bandung, Indonesia.
Abstract
PURPOSE: To evaluate the histopathological characteristics of clinically advanced retinoblastoma (RB) and its relationship with tumor differentiation. METHODS: This was a cross-sectional study of primary enucleated group D/E intraocular RB using medical records from 2017 to 2020 in a tertiary referral hospital. Cases with incomplete histopathological results were excluded. Tumors were classified into well, moderately, and poorly differentiated and undifferentiated. High-risk histopathological features were classified as per Thaung and Karaa [Community Eye Health. 2018;31(101):17-3]. RESULTS: This study included 121 patients (129 eyes), of which 32.2% were diagnosed at 25-36 months. High-risk features (HRFs) were found in 100/129 eyes, and of 73 complete histopathological results, the 2 most common HRFs were postlaminar optic nerve invasion and massive choroidal invasion. RB was poorly differentiated in 69.9% and well differentiated in 12.3% of eyes. There was no statistically significant association between any HRFs and tumor differentiation, with age >2 years associated with tumor differentiation (p < 0.05). CONCLUSION: The frequency of HRFs is 77.5% of primary enucleated eyes, mainly poorly and undifferentiated cells, particularly in children aged >2 years old.
PURPOSE: To evaluate the histopathological characteristics of clinically advanced retinoblastoma (RB) and its relationship with tumor differentiation. METHODS: This was a cross-sectional study of primary enucleated group D/E intraocular RB using medical records from 2017 to 2020 in a tertiary referral hospital. Cases with incomplete histopathological results were excluded. Tumors were classified into well, moderately, and poorly differentiated and undifferentiated. High-risk histopathological features were classified as per Thaung and Karaa [Community Eye Health. 2018;31(101):17-3]. RESULTS: This study included 121 patients (129 eyes), of which 32.2% were diagnosed at 25-36 months. High-risk features (HRFs) were found in 100/129 eyes, and of 73 complete histopathological results, the 2 most common HRFs were postlaminar optic nerve invasion and massive choroidal invasion. RB was poorly differentiated in 69.9% and well differentiated in 12.3% of eyes. There was no statistically significant association between any HRFs and tumor differentiation, with age >2 years associated with tumor differentiation (p < 0.05). CONCLUSION: The frequency of HRFs is 77.5% of primary enucleated eyes, mainly poorly and undifferentiated cells, particularly in children aged >2 years old.
Authors: Ido D Fabian; Andrew W Stacey; Tanzina Chowdhury; Catriona Duncan; Esin K Karaa; Irene Scheimberg; M Ashwin Reddy; Mandeep S Sagoo Journal: Ophthalmology Date: 2017-03-13 Impact factor: 12.079