INTRODUCTION: The purpose of this study is to describe variations in microvasculature before and after treatment of treatment-naive lesions and during consolidation therapy of retinoblastoma lesions using an investigational portable optical coherence tomography angiography (OCTA) system. METHODS: This study is a single-center, prospective, observational case series. Recruited subjects were either undergoing surveillance for retinoblastoma or had newly detected retinoblastoma. Nine tumors from 7 eyes in 6 patients were included. During exams under anesthesia, the tumors were imaged with an investigational portable OCTA system. OCTA images were analyzed to assess vascular changes before and after treatment. RESULTS: In all 6 presented cases, OCTA imaging revealed distinctive vascular patterns, such as dilated feeder arteries and draining veins, disorganized and complex branching patterns, irregular vessel calibers, and dilation and tortuosity of vessels. After treatment, OCTA imaging revealed decreased intrinsic tumor vascularity and reduced dilation of draining and feeder vessels. Tumor relapse demonstrated prominent vascularity (n = 1) that resolved on repeat OCTA after transpupillary thermotherapy treatment. Type 2 (n = 1), 3 (n = 6), and 4 (n = 1) tumor regression patterns were seen in our patients after treatment, and OCTA findings were consistent with a previously published report. Interestingly, in one of the presented cases, OCTA demonstrated clear feeder, draining, and intrinsic tumor vessels that were not as evident on fluorescein angiography. CONCLUSIONS: OCTA may offer a noninvasive and sensitive technique to evaluate the vasculature of both the tumor and the surrounding retina in retinoblastoma. With additional research and development into its use in patients with retinoblastoma, OCTA may one day be useful in assessing treatment response and residual tumor activity.
INTRODUCTION: The purpose of this study is to describe variations in microvasculature before and after treatment of treatment-naive lesions and during consolidation therapy of retinoblastoma lesions using an investigational portable optical coherence tomography angiography (OCTA) system. METHODS: This study is a single-center, prospective, observational case series. Recruited subjects were either undergoing surveillance for retinoblastoma or had newly detected retinoblastoma. Nine tumors from 7 eyes in 6 patients were included. During exams under anesthesia, the tumors were imaged with an investigational portable OCTA system. OCTA images were analyzed to assess vascular changes before and after treatment. RESULTS: In all 6 presented cases, OCTA imaging revealed distinctive vascular patterns, such as dilated feeder arteries and draining veins, disorganized and complex branching patterns, irregular vessel calibers, and dilation and tortuosity of vessels. After treatment, OCTA imaging revealed decreased intrinsic tumor vascularity and reduced dilation of draining and feeder vessels. Tumor relapse demonstrated prominent vascularity (n = 1) that resolved on repeat OCTA after transpupillary thermotherapy treatment. Type 2 (n = 1), 3 (n = 6), and 4 (n = 1) tumor regression patterns were seen in our patients after treatment, and OCTA findings were consistent with a previously published report. Interestingly, in one of the presented cases, OCTA demonstrated clear feeder, draining, and intrinsic tumor vessels that were not as evident on fluorescein angiography. CONCLUSIONS: OCTA may offer a noninvasive and sensitive technique to evaluate the vasculature of both the tumor and the surrounding retina in retinoblastoma. With additional research and development into its use in patients with retinoblastoma, OCTA may one day be useful in assessing treatment response and residual tumor activity.
Authors: S Tammy Hsu; Xi Chen; Hoan T Ngo; Robert J House; Michael P Kelly; Laura B Enyedi; Miguel A Materin; Mays Antoine El-Dairi; Sharon F Freedman; Cynthia A Toth; Lejla Vajzovic Journal: Ophthalmol Retina Date: 2018-07-26
Authors: Oleg Nadiarnykh; Valentina Davidoiu; Maximilian G O Gräfe; Machteld Bosscha; Annette C Moll; Johannes F de Boer Journal: Biomed Opt Express Date: 2019-04-03 Impact factor: 3.732
Authors: Carlos Bianciotto; Carol L Shields; Juan C Iturralde; Ahmet Sarici; Pascal Jabbour; Jerry A Shields Journal: Ophthalmology Date: 2011-12-02 Impact factor: 12.079
Authors: Avni P Finn; Robert J House; S Tammy Hsu; Akshay S Thomas; Mays A El-Dairi; Sharon Freedman; Miguel A Materin; Lejla Vajzovic Journal: Ophthalmic Surg Lasers Imaging Retina Date: 2019-01-01 Impact factor: 1.300
Authors: Akshay S Thomas; S Tammy Hsu; Robert J House; Avni P Finn; Michael P Kelly; Cynthia A Toth; Miguel A Materin; Lejla Vajzovic Journal: Ophthalmic Surg Lasers Imaging Retina Date: 2019-12-01 Impact factor: 1.300