Célina Alexandra Fehr1, Philip Went2, Martina Maranta3, Richard Cathomas1. 1. Department of Internal Medicine, Division of Oncology/Hematology, Cantonal Hospital of Graubünden, Chur, Switzerland. 2. Department of Pathology, Cantonal Hospital of Graubünden, Chur, Switzerland. 3. Department of Gynecology, Cantonal Hospital of Graubünden, Chur, Switzerland.
Abstract
INTRODUCTION: Primary breast malignancy in adolescent women is very rare and differs in several aspects from findings in adult women. CASE PRESENTATION: A young woman aged 16 years presented with a locally aggressive breast tumor. The patient received cisplatin-based chemotherapy followed by tumor resection assuming a diagnosis of germ cell tumor. Four months later, she developed locally recurrent disease and underwent a mastectomy. No definite diagnosis was agreed upon despite intensive pathological workup. Subsequent management consisted of follow-up only and the patient remains in complete remission 9 years later. CONCLUSION: This case demonstrates the difficulty of diagnosis and management of rare malignancies in adolescents, and highlights the importance of international and interdisciplinary collaboration in diagnosis and clinical decision-making.
INTRODUCTION: Primary breast malignancy in adolescent women is very rare and differs in several aspects from findings in adult women. CASE PRESENTATION: A young woman aged 16 years presented with a locally aggressive breast tumor. The patient received cisplatin-based chemotherapy followed by tumor resection assuming a diagnosis of germ cell tumor. Four months later, she developed locally recurrent disease and underwent a mastectomy. No definite diagnosis was agreed upon despite intensive pathological workup. Subsequent management consisted of follow-up only and the patient remains in complete remission 9 years later. CONCLUSION: This case demonstrates the difficulty of diagnosis and management of rare malignancies in adolescents, and highlights the importance of international and interdisciplinary collaboration in diagnosis and clinical decision-making.
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Authors: Duncan Sproul; Robert R Kitchen; Colm E Nestor; J Michael Dixon; Andrew H Sims; David J Harrison; Bernard H Ramsahoye; Richard R Meehan Journal: Genome Biol Date: 2012-10-03 Impact factor: 13.583