| Literature DB >> 3472019 |
U R Kees, J Ford, P J Price, B F Meyer, R P Herrmann.
Abstract
A new cell line, PER-117, was established from bone marrow cells of an eighteen months old boy with an acute lymphoblastic leukaemia (ALL). The leukaemic origin of cell line PER-117 is indicated by its cytochemical, immunological and cytogenetic similarity to the patient's fresh leukaemic cells. PER-117 carries a marker chromosome which was identified as a translocation between chromosomes 1 and 11. The surface marker analysis revealed that the phenotype of PER-117 is RFB-1+, RFT-1+ (CD5), 3A1+ (CD7), OKT 9+, OKT 10+ and HLA-DR-. Thus, this cell line appears to represent a prothymocyte or stage I thymocyte and preliminary data suggest that it can be induced in vitro to further differentiate.Entities:
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Year: 1987 PMID： 3472019 DOI： 10.1016/0145-2126(87)90082-8
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156