Literature DB >> 3471814

Immune response gene products (Ia antigens) on glial and endothelial cells in virus-induced demyelination.

M Rodriguez, M L Pierce, E A Howie.   

Abstract

Theiler's murine encephalomyelitis virus induced central nervous system demyelination in susceptible strains of mice with s, q, v, p, and f H-2D alleles. We used immunoelectron microscopy to look for differential production of class II immune response gene products (Ia) within astrocytes, oligodendrocytes, microglia, and endothelial cells. Spinal cord sections from susceptible mice (B10.S and B10.ASR2) showed increased content of Ia in glial and endothelial cells. In contrast, resistant mice [B10.S(9R)] showed minimal Ia production within the CNS. The findings indicate an important role of class II immune response products on glial cells during demyelination after virus infection.

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Year:  1987        PMID： 3471814

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  29 in total

Review 1.  Astrocytes and intracerebral immune responses.

Authors:  E M Frohman; S van den Noort; S Gupta
Journal:  J Clin Immunol       Date:  1989-01       Impact factor: 8.317

2.  MHC-chromosome dosage effects: evidence for increased expression of Ia glycoprotein and alteration of B cell subpopulations in neonatal aneuploid chickens.

Authors:  M E Delany; R R Dietert; S E Bloom
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

3.  Characterization of mouse hepatitis virus-specific cytotoxic T cells derived from the central nervous system of mice infected with the JHM strain.

Authors:  S A Stohlman; S Kyuwa; J M Polo; D Brady; M M Lai; C C Bergmann
Journal:  J Virol       Date:  1993-12       Impact factor: 5.103

4.  Expression of the human histocompatibility leukocyte antigen DR3 transgene reduces the severity of demyelination in a murine model of multiple sclerosis.

Authors:  K M Drescher; L T Nguyen; V Taneja; M J Coenen; J L Leibowitz; G Strauss; G J Hammerling; C S David; M Rodriguez
Journal:  J Clin Invest       Date:  1998-04-15       Impact factor: 14.808

5.  Theiler's virus infection in nude mice: viral RNA in vascular endothelial cells.

Authors:  A Zurbriggen; R S Fujinami
Journal:  J Virol       Date:  1988-10       Impact factor: 5.103

6.  Susceptibility to Theiler's virus-induced demyelinating disease correlates with astrocyte class II induction and antigen presentation.

Authors:  P Borrow; A A Nash
Journal:  Immunology       Date:  1992-05       Impact factor: 7.397

7.  Feline immunodeficiency virus decreases cell-cell communication and mitochondrial membrane potential.

Authors:  I R Danave; E Tiffany-Castiglioni; E Zenger; R Barhoumi; R C Burghardt; E W Collisson
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103

8.  Nonhuman primate parthenogenetic stem cells.

Authors:  Kent E Vrana; Jason D Hipp; Ashley M Goss; Brian A McCool; David R Riddle; Stephen J Walker; Peter J Wettstein; Lorenz P Studer; Viviane Tabar; Kerrianne Cunniff; Karen Chapman; Lucy Vilner; Michael D West; Kathleen A Grant; Jose B Cibelli
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-22       Impact factor: 11.205

9.  Paralysis of street rabies virus-infected mice is dependent on T lymphocytes.

Authors:  M Sugamata; M Miyazawa; S Mori; G J Spangrude; L C Ewalt; D L Lodmell
Journal:  J Virol       Date:  1992-02       Impact factor: 5.103

10.  Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal infection without eliminating virus from the central nervous system.

Authors:  S A Stohlman; C C Bergmann; R C van der Veen; D R Hinton
Journal:  J Virol       Date:  1995-02       Impact factor: 5.103
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