Effects and signaling pathways of Elabela in the cardiovascular system.

For a long time, Apelin has been considered as the only endogenous ligand of G protein-coupled receptor APJ. Until recently, the discovery of Elabela (Apela/Toddler) as a new polypeptide that can act through APJ and has a similar function to Apelin broke this situation. Elabela promotes a variety of cell proliferation processes, including embryonic development, and has especially beneficial effects in the cardiovascular system. In this review, we summarize the biological functions of Elabela and review its specific roles in cardiovascular diseases and the signaling pathways mediated by it.