Literature DB >> 3471702

Hydatidiform mole: genetic origin in polyploid conceptuses.

L O Vejerslev, J Dissing, H E Hansen, H Poulsen.   

Abstract

The origin of 29 polyploid conceptuses with villous cystic swelling was examined. One tetraploid specimen showed one maternal and three paternal contributions to the genome. Informative cytogenetic markers in 24 triploids were consistent with fertilization by dispermy. Analysis of cytogenetic markers indicated that polyspermy may account for essentially all polyploid conceptions with an excess of paternal to maternal chromosome complements. The origin of the genome was primarily demonstrated by the study of cytogenetic markers, while HLA determination and enzyme analysis were less informative.

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Year:  1987        PMID： 3471702     DOI： 10.1007/BF00283043

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  28 in total

1.  Tetraploid partial hydatidiform moles: two cases with a triple paternal contribution and a 92,XXXY karyotype.

Authors:  U Surti; A E Szulman; K Wagner; M Leppert; S J O'Brien
Journal:  Hum Genet       Date:  1986-01       Impact factor: 4.132

2.  Inversion duplication of chromosome 6 with trisomic codominant expression of HLA antigens.

Authors:  G Pearson; J D Mann; J Bensen; R W Bull
Journal:  Am J Hum Genet       Date:  1979-01       Impact factor: 11.025

3.  Dispermy as the origin of partial moles as well as a nonmolar conception.

Authors:  L O Vejerslev; K Kristoffersen; H Lopez
Journal:  Gynecol Obstet Invest       Date:  1986       Impact factor: 2.031

4.  Origin of human trisomics and polyploids.

Authors:  P A Jacobs; N E Morton
Journal:  Hum Hered       Date:  1977       Impact factor: 0.444

5.  Hydatidiform mole in Nottingham: a 12-year retrospective epidemiological and morphological study.

Authors:  C Womack; C W Elston
Journal:  Placenta       Date:  1985 Mar-Apr       Impact factor: 3.481

6.  Identification of the origin of triploidy by HLA markers.

Authors:  P Couillin; J Hors; J Boué; A Boué
Journal:  Hum Genet       Date:  1978-02-23       Impact factor: 4.132

7.  Human red cell acid phosphatase: quantitative evidence of a silent gene PO, and a Danish population study.

Authors:  J Dissing; O Svensmark
Journal:  Hum Hered       Date:  1976       Impact factor: 0.444

8.  Parental origin of chromosome abnormalities in spontaneous abortions.

Authors:  G H Meulenbroek; J P Geraedts
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

9.  Hydatidiform mole: genetic markers in diploid abortuses with macroscopic villous enlargement.

Authors:  L O Vejerslev; J Dissing; H E Hansen; H Poulsen
Journal:  Cancer Genet Cytogenet       Date:  1987-05

10.  Origin of triploidy and tetraploidy in man: 11 cases with chromosomes markers.

Authors:  T Kajii; N Niikawa
Journal:  Cytogenet Cell Genet       Date:  1977
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  4 in total

1.  Parental origin of triploidy in human fetuses: evidence for genomic imprinting.

Authors:  D E McFadden; L C Kwong; I Y Yam; S Langlois
Journal:  Hum Genet       Date:  1993-11       Impact factor: 4.132

2.  Analyzing the most frequent disease loci in targeted patient categories optimizes disease gene identification and test accuracy worldwide.

Authors:  Roger V Lebo; Vijay S Tonk
Journal:  J Transl Med       Date:  2015-01-21       Impact factor: 5.531

3.  Whole-exome sequencing reveals genetic variants in ERC1 and KCNG4 associated with complete hydatidiform mole in Chinese Han women.

Authors:  Yan Yu; Bingjian Lu; Weiguo Lu; Shuang Li; Xiuqin Li; Xinyu Wang; Xiaoyun Wan; Yaxia Chen; Suwen Feng; Yao Jia; Ru Yang; Fangxu Tang; Xiong Li; Shulan Zhang; Xinyan Wang; Heng Wei; Zhilan Peng; Lin Lu; Huizhen Zhong; Linjun Zhao; Zhangqian Huang; Lin Lin; Weihong Shen; Yan Lu; Zhu Cao; Jian Zou; Yuejiang Ma; Xiaojing Chen; Qifang Tian; Shiming Lu; Pengyuan Liu; Ding Ma; Xing Xie; Xiaodong Cheng
Journal:  Oncotarget       Date:  2017-09-08

4.  Establishment and characterization of cell lines derived from complete hydatidiform mole.

Authors:  Eiko Yamamoto; Kaoru Niimi; Tohru Kiyono; Toshimichi Yamamoto; Kimihiro Nishino; Kenichi Nakamura; Tomomi Kotani; Hiroaki Kajiyama; Kiyosumi Shibata; Fumitaka Kikkawa
Journal:  Int J Mol Med       Date:  2017-07-14       Impact factor: 4.101
  4 in total

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