Literature DB >> 34716239

Podocyte Aging: Why and How Getting Old Matters.

Stuart J Shankland1,2, Yuliang Wang2,3, Andrey S Shaw4, Joshua C Vaughan5,6, Jeffrey W Pippin7, Oliver Wessely8.   

Abstract

The effects of healthy aging on the kidney, and how these effects intersect with superimposed diseases, are highly relevant in the context of the population's increasing longevity. Age-associated changes to podocytes, which are terminally differentiated glomerular epithelial cells, adversely affect kidney health. This review discusses the molecular and cellular mechanisms underlying podocyte aging, how these mechanisms might be augmented by disease in the aged kidney, and approaches to mitigate progressive damage to podocytes. Furthermore, we address how biologic pathways such as those associated with cellular growth confound aging in humans and rodents.
Copyright © 2021 by the American Society of Nephrology.

Entities:  

Keywords:  RNA sequencing; aging; glomerulosclerosis; glomerulus; podocyte; senescence

Mesh：

Substances：

Year:  2021        PMID： 34716239      PMCID： PMC8806106          DOI： 10.1681/ASN.2021050614

Source DB:  PubMed          Journal:  J Am Soc Nephrol        ISSN： 1046-6673            Impact factor:   10.121


  185 in total

1.  Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts.

Authors:  T von Zglinicki; R Pilger; N Sitte
Journal:  Free Radic Biol Med       Date:  2000-01-01       Impact factor: 7.376

2.  Angiotensin II-dependent persistent podocyte loss from destabilized glomeruli causes progression of end stage kidney disease.

Authors:  Akihiro Fukuda; Larysa T Wickman; Madhusudan P Venkatareddy; Yuji Sato; Mahboob A Chowdhury; Su Q Wang; Kerby A Shedden; Robert C Dysko; Jocelyn E Wiggins; Roger C Wiggins
Journal:  Kidney Int       Date:  2011-09-21       Impact factor: 10.612

3.  The association between age and nephrosclerosis on renal biopsy among healthy adults.

Authors:  Andrew D Rule; Hatem Amer; Lynn D Cornell; Sandra J Taler; Fernando G Cosio; Walter K Kremers; Stephen C Textor; Mark D Stegall
Journal:  Ann Intern Med       Date:  2010-05-04       Impact factor: 25.391

Review 4.  Gender-dependent effects of aging on the kidney.

Authors:  A L Gava; F P S Freitas; S S Meyrelles; I V Silva; J B Graceli
Journal:  Braz J Med Biol Res       Date:  2011-08-19       Impact factor: 2.590

5.  Nephrin Preserves Podocyte Viability and Glomerular Structure and Function in Adult Kidneys.

Authors:  Xuezhu Li; Peter Y Chuang; Vivette D D'Agati; Yan Dai; Rabi Yacoub; Jia Fu; Jin Xu; Oltjon Taku; Prem K Premsrirut; Lawrence B Holzman; John Cijiang He
Journal:  J Am Soc Nephrol       Date:  2015-02-02       Impact factor: 10.121

6.  Reduced insulin/IGF-1 signalling and human longevity.

Authors:  Diana van Heemst; Marian Beekman; Simon P Mooijaart; Bastiaan T Heijmans; Bernd W Brandt; Bas J Zwaan; P Eline Slagboom; Rudi G J Westendorp
Journal:  Aging Cell       Date:  2005-04       Impact factor: 9.304

7.  Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat.

Authors:  Y H Kim; M Goyal; D Kurnit; B Wharram; J Wiggins; L Holzman; D Kershaw; R Wiggins
Journal:  Kidney Int       Date:  2001-09       Impact factor: 10.612

8.  Podocyte hypertrophy, "adaptation," and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction.

Authors:  Jocelyn E Wiggins; Meera Goyal; Silja K Sanden; Bryan L Wharram; Kerby A Shedden; David E Misek; Rork D Kuick; Roger C Wiggins
Journal:  J Am Soc Nephrol       Date:  2005-08-24       Impact factor: 10.121

9.  Prevalence of chronic kidney disease in the United States.

Authors:  Josef Coresh; Elizabeth Selvin; Lesley A Stevens; Jane Manzi; John W Kusek; Paul Eggers; Frederick Van Lente; Andrew S Levey
Journal:  JAMA       Date:  2007-11-07       Impact factor: 56.272

Review 10.  Podocytes in culture: past, present, and future.

Authors:  S J Shankland; J W Pippin; J Reiser; P Mundel
Journal:  Kidney Int       Date:  2007-04-25       Impact factor: 10.612
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  6 in total

1.  The ability of remaining glomerular podocytes to adapt to the loss of their neighbours decreases with age.

Authors:  James van der Wolde; Kotaro Haruhara; Victor G Puelles; David Nikolic-Paterson; John F Bertram; Luise A Cullen-McEwen
Journal:  Cell Tissue Res       Date:  2022-03-15       Impact factor: 4.051

Review 2.  Healthy and unhealthy aging on kidney structure and function: human studies.

Authors:  Aleksandar Denic; Andrew D Rule; Richard J Glassock
Journal:  Curr Opin Nephrol Hypertens       Date:  2022-01-25       Impact factor: 3.416

3.  Aged glomeruli: a link between PD-1 and podocytes.

Authors:  Samuel Mon-Wei Yu; John Cijiang He
Journal:  J Clin Invest       Date:  2022-08-15       Impact factor: 19.456

4.  Upregulated PD-1 signaling antagonizes glomerular health in aged kidneys and disease.

Authors:  Jeffrey W Pippin; Natalya Kaverina; Yuliang Wang; Diana G Eng; Yuting Zeng; Uyen Tran; Carol J Loretz; Anthony Chang; Shreeram Akilesh; Chetan Poudel; Hannah S Perry; Christopher O'Connor; Joshua C Vaughan; Markus Bitzer; Oliver Wessely; Stuart J Shankland
Journal:  J Clin Invest       Date:  2022-08-15       Impact factor: 19.456

5.  The role of PTEN in puromycin aminonucleoside-induced podocyte injury.

Authors:  Qi Ren; Shengyou Yu; Huasong Zeng; Huimin Xia
Journal:  Int J Med Sci       Date:  2022-08-15       Impact factor: 3.642

6.  Role of Arginase-II in Podocyte Injury under Hypoxic Conditions.

Authors:  Zhilong Ren; Duilio Michele Potenza; Yiqiong Ma; Guillaume Ajalbert; David Hoogewijs; Xiu-Fen Ming; Zhihong Yang
Journal:  Biomolecules       Date:  2022-08-31
  6 in total

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