| Literature DB >> 34716027 |
Zhengming Zhu1, Liying Zhu2, Ling Jiang3.
Abstract
Short-chain fatty acids (SCFAs) are major products of intestinal microbial fermentation with beneficial effects for human health. The dynamic balance and real-time monitoring of endogenous SCFA biosynthesis are important for understanding their physiological functions. We discuss the promising future of applying CRISPRi genetic systems and biosensors for targeted SCFA improvement.Entities:
Keywords: CRISPRi genetic system; biosensor; gut Clostridium; short-chain fatty acids; synthetic biology
Mesh:
Substances:
Year: 2021 PMID: 34716027 DOI: 10.1016/j.tibtech.2021.10.005
Source DB: PubMed Journal: Trends Biotechnol ISSN: 0167-7799 Impact factor: 19.536