Albraa Abulhamail1, Saif Selati2, Rakan Alasqah2. 1. King Abdulaziz University, 7239 Ahmad Zaynal, As Salamah District, Jeddah, Saudi Arabia. caandor@icloud.com. 2. King Khalid National Guard Hospital, Jeddah, Saudi Arabia.
Abstract
INTRODUCTION: The prevalence of stroke in SCD patients was reported to be around 4%; however, the pediatric category was among the higher risk group for stroke compared to young and middle age adults. Furthermore, the risk of OSA increases in SCD children. The objective of this study is to calculate the prevalence of stroke in children with SCD with and without obstructive sleep apnea. METHOD: This is a cross-sectional study held at two major tertiary hospitals in Jeddah, Saudi Arabia. Inclusion criteria included patients aged between 2 and 18 at the time of enrollment with confirmed SCD. The primary outcome of the study was at least one documented episode of stroke over the last 3 years. OSA was assessed using PSQ. RESULTS: A total of 150 children with SCD were included in the study. The mean age was 9.6 (±4.3). Most of the sample (85.3%) were sickle-cell anemia with HbSS. Children who were positive for OSA were at higher odds of having a stroke [OR 2.97; 95% CI 1.13-7.75 (P = 0.02)]. The relationship between OSA and stroke was not significant in the multivariant analysis. CONCLUSION: Patients who had OSA had a higher prevalence of stroke compared to non-OSA patients by 16% with almost three times higher odds. The difference was statistically significant in bivariant but not multivariant analysis. The rate of hospitalization, emergency visit, and blood transfusion were not affected by OSA status. Screening for OSA in high-risk patients such as SCD children and early management could prevent the risk of SCD complications.
INTRODUCTION: The prevalence of stroke in SCD patients was reported to be around 4%; however, the pediatric category was among the higher risk group for stroke compared to young and middle age adults. Furthermore, the risk of OSA increases in SCD children. The objective of this study is to calculate the prevalence of stroke in children with SCD with and without obstructive sleep apnea. METHOD: This is a cross-sectional study held at two major tertiary hospitals in Jeddah, Saudi Arabia. Inclusion criteria included patients aged between 2 and 18 at the time of enrollment with confirmed SCD. The primary outcome of the study was at least one documented episode of stroke over the last 3 years. OSA was assessed using PSQ. RESULTS: A total of 150 children with SCD were included in the study. The mean age was 9.6 (±4.3). Most of the sample (85.3%) were sickle-cell anemia with HbSS. Children who were positive for OSA were at higher odds of having a stroke [OR 2.97; 95% CI 1.13-7.75 (P = 0.02)]. The relationship between OSA and stroke was not significant in the multivariant analysis. CONCLUSION: Patients who had OSA had a higher prevalence of stroke compared to non-OSA patients by 16% with almost three times higher odds. The difference was statistically significant in bivariant but not multivariant analysis. The rate of hospitalization, emergency visit, and blood transfusion were not affected by OSA status. Screening for OSA in high-risk patients such as SCD children and early management could prevent the risk of SCD complications.
Authors: Marelle J Bouva; Karin Mohrmann; Henri B J M Brinkman; Evelien A Kemper-Proper; Bert Elvers; J Gerard Loeber; Francesco E A M Verheul; Piero C Giordano Journal: J Med Screen Date: 2010 Impact factor: 2.136
Authors: J Bardakdjian-Michau; M Bahuau; D Hurtrel; C Godart; J Riou; M Mathis; M Goossens; C Badens; R Ducrocq; J Elion; J M Perini Journal: J Clin Pathol Date: 2009-01 Impact factor: 3.411
Authors: Grace Ndeezi; Charles Kiyaga; Arielle G Hernandez; Deogratias Munube; Thad A Howard; Isaac Ssewanyana; Jesca Nsungwa; Sarah Kiguli; Christopher M Ndugwa; Russell E Ware; Jane R Aceng Journal: Lancet Glob Health Date: 2016-01-29 Impact factor: 26.763
Authors: Mavis Oppong; Helena Lamptey; Eric Kyei-Baafour; Belinda Aculley; Ebenezer Addo Ofori; Bernard Tornyigah; Margaret Kweku; Michael F Ofori Journal: Malar J Date: 2020-11-23 Impact factor: 2.979
Authors: Frédéric B Piel; Anand P Patil; Rosalind E Howes; Oscar A Nyangiri; Peter W Gething; Mewahyu Dewi; William H Temperley; Thomas N Williams; David J Weatherall; Simon I Hay Journal: Lancet Date: 2012-10-25 Impact factor: 79.321