Shiyan Wang1,2, Lei Gao1,2, Hongwu Wen3, Yunong Gao4, Qiubo Lv5, Hongyu Li6, Sumei Wang7, Yanlong Wang8, Qing Liu9, Jinsong Han10, Haibo Wang11, Yi Li12, Na Yu12, Qing Wang1,2, Tingting Cao1,2, Sha Wang1,2, Huaxin Sun1,2, Zhiqi Wang1,2, Xiuli Sun13,14, Jianliu Wang15,16. 1. Department of OB/Gyn, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng Dist., Beijing, 100044, China. 2. Beijing Key Laboratory of Female Pelvic Floor Disorders, Beijing, China. 3. Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China. 4. Department of Gynecology, Peking University Cancer Hospital & Institute, Beijing, China. 5. Department of Obstetrics and Gynecology, Beijing Hospital, Beijing, China. 6. Department of Obstetrics and Gynecology, Zhengzhou University Third Hospital, Zhengzhou, Henan, China. 7. Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. 8. Department of Obstetrics and Gynecology, Women and Children Health Hospital of Xiamen, Xiamen, China. 9. Department of Obstetrics and Gynecology, Women and Children Health Hospital of Gansu, Lanzhou, Gansu, China. 10. Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. 11. Peking University Clinical Research Institute, Beijing, China. 12. Information Center, Peking University Health Science Center, Beijing, China. 13. Department of OB/Gyn, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng Dist., Beijing, 100044, China. sunxiuli03351@126.com. 14. Beijing Key Laboratory of Female Pelvic Floor Disorders, Beijing, China. sunxiuli03351@126.com. 15. Department of OB/Gyn, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng Dist., Beijing, 100044, China. wangjianliu1203@163.com. 16. Beijing Key Laboratory of Female Pelvic Floor Disorders, Beijing, China. wangjianliu1203@163.com.
Abstract
INTRODUCTION: To evaluate the pelvic floor muscle function (PFMF) of cervical cancer patients after type QM-C hysterectomy and to explore the relationship between decreased PFMF and related factors. METHODS: This was a multi-centered retrospective cohort study. 181 cervical cancer patients who underwent type QM-C hysterectomy were enrolled from 9 tertiary hospitals. Strength of PFMF were measured using neuromuscular apparatus (Phenix U8, French). Risk factors contributing to decreased PFMF were analyzed by univariate and multivariate ordinal polytomous logistic regression. RESULTS: Totally 181 patients were investigated in this study. 0-3 level of type I muscle fibre strength (MFSI) was 52.6% (95/181), 0-3 level of type IIA muscle fibre strength (MFSIIA) was 50% (91/181). Subjective stress urinary incontinence was 46% (84/181), urinary retention was 27.3% (50/181), dyschezia was 41.5% (75/181), fecal incontinence was 9% (18/181). ① MFSI: Multivariate ordinal polytomous logistic regression shows that the follow-up time (p < 0.05), chemotherapy and radiotherapy (p = 0.038) are independent risk factors of MFSI's reduction after type QM-C hysterectomy. ② MFSIIA: multivariate ordinal polytomous logistic regression shows that the follow-up time (p < 0.05) are independent risk factors of MFSIIA's reduction after type QM-C hysterectomy. The pelvic floor muscle strength (PFMS) increased after 9 months than in 9 months after operation, which showed that the PFMS could be recovered after operation. CONCLUSIONS: We advocate for more attention and emphasis on the PFMF of Chinese female patients with cervical cancer postoperation. PEKING UNIVERSITY PEOPLE'S HOSPITAL: PFMF after QM-C hysterectomy has not been analyzed by current study. The contribution is that patients with radical hysterectomy should do pelvic floor rehabilitation exercises in 3 months after operation. Clinical Trails NCT number of this study is 02492542.
INTRODUCTION: To evaluate the pelvic floor muscle function (PFMF) of cervical cancer patients after type QM-C hysterectomy and to explore the relationship between decreased PFMF and related factors. METHODS: This was a multi-centered retrospective cohort study. 181 cervical cancer patients who underwent type QM-C hysterectomy were enrolled from 9 tertiary hospitals. Strength of PFMF were measured using neuromuscular apparatus (Phenix U8, French). Risk factors contributing to decreased PFMF were analyzed by univariate and multivariate ordinal polytomous logistic regression. RESULTS: Totally 181 patients were investigated in this study. 0-3 level of type I muscle fibre strength (MFSI) was 52.6% (95/181), 0-3 level of type IIA muscle fibre strength (MFSIIA) was 50% (91/181). Subjective stress urinary incontinence was 46% (84/181), urinary retention was 27.3% (50/181), dyschezia was 41.5% (75/181), fecal incontinence was 9% (18/181). ① MFSI: Multivariate ordinal polytomous logistic regression shows that the follow-up time (p < 0.05), chemotherapy and radiotherapy (p = 0.038) are independent risk factors of MFSI's reduction after type QM-C hysterectomy. ② MFSIIA: multivariate ordinal polytomous logistic regression shows that the follow-up time (p < 0.05) are independent risk factors of MFSIIA's reduction after type QM-C hysterectomy. The pelvic floor muscle strength (PFMS) increased after 9 months than in 9 months after operation, which showed that the PFMS could be recovered after operation. CONCLUSIONS: We advocate for more attention and emphasis on the PFMF of Chinese female patients with cervical cancer postoperation. PEKING UNIVERSITY PEOPLE'S HOSPITAL: PFMF after QM-C hysterectomy has not been analyzed by current study. The contribution is that patients with radical hysterectomy should do pelvic floor rehabilitation exercises in 3 months after operation. Clinical Trails NCT number of this study is 02492542.
Authors: Francesco Plotti; Corrado Terranova; Stella Capriglione; Stefania Crispino; Alessandra Li Pomi; Carlo de Cicco Nardone; Roberto Montera; Pierluigi Benedetti Panici; Roberto Angioli; Giuseppe Scaletta Journal: Int J Gynecol Cancer Date: 2018-05 Impact factor: 3.437