| Literature DB >> 34711977 |
Jiayuan Xu1,2, Xiaoxuan Liu3, Qiaojun Li4, Ran Goldblatt5, Wen Qin1, Feng Liu1, Congying Chu2, Qiang Luo6,7, Alex Ing2, Lining Guo1, Nana Liu1, Huaigui Liu1, Conghong Huang3, Jingliang Cheng8, Meiyun Wang9, Zuojun Geng10, Wenzhen Zhu11, Bing Zhang12, Weihua Liao13, Shijun Qiu14, Hui Zhang15, Xiaojun Xu16, Yongqiang Yu17, Bo Gao18, Tong Han19, Guangbin Cui20, Feng Chen21, Junfang Xian22, Jiance Li23, Jing Zhang24, Xi-Nian Zuo25, Dawei Wang26, Wen Shen27, Yanwei Miao28, Fei Yuan29, Su Lui30, Xiaochu Zhang31, Kai Xu32, Longjiang Zhang33, Zhaoxiang Ye34, Tobias Banaschewski35, Gareth J Barker36, Arun L W Bokde37, Herta Flor38,39, Antoine Grigis40, Hugh Garavan41, Penny Gowland42, Andreas Heinz43, Rüdiger Brühl44, Jean-Luc Martinot45, Eric Artiges46, Frauke Nees35,38, Dimitri Papadopoulos Orfanos40, Herve Lemaitre47, Tomáš Paus48,49, Luise Poustka50, Lauren Robinson51, Sarah Hohmann35, Juliane H Fröhner52, Michael N Smolka52, Henrik Walter43, Robert Whelan53, Jeanne Winterer54,55, Kevin Patrick56, Vince Calhoun57, Mulin Jun Li58, Meng Liang59, Peng Gong3,60, Edward D Barker51, Nicholas Clinton61, Andre Marquand62, Le Yu3, Chunshui Yu63,64, Gunter Schumann65,66.
Abstract
Urbanicity is a growing environmental challenge for mental health. Here, we investigate correlations of urbanicity with brain structure and function, neuropsychology and mental illness symptoms in young people from China and Europe (total n = 3,867). We developed a remote-sensing satellite measure (UrbanSat) to quantify population density at any point on Earth. UrbanSat estimates of urbanicity were correlated with brain volume, cortical surface area and brain network connectivity in the medial prefrontal cortex and cerebellum. UrbanSat was also associated with perspective-taking and depression symptoms, and this was mediated by neural variables. Urbanicity effects were greatest when urban exposure occurred in childhood for the cerebellum, and from childhood to adolescence for the prefrontal cortex. As UrbanSat can be generalized to different geographies, it may enable assessments of correlations of urbanicity with mental illness and resilience globally.Entities:
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Year: 2021 PMID： 34711977 DOI： 10.1038/s41562-021-01204-7
Source DB: PubMed Journal: Nat Hum Behav ISSN： 2397-3374