Literature DB >> 34709373

Characteristics and Outcomes of US Patients Hospitalized With COVID-19.

Ithan D Peltan1, Ellen Caldwell2, Andrew J Admon3, Engi F Attia4, Stephanie J Gundel5, Kusum S Mathews6, Alexander Nagrebetsky7, Sarina K Sahetya8, Christine Ulysse9, Samuel M Brown10, Steven Y Chang11, Andrew J Goodwin12, Aluko A Hope13, Theodore J Iwashyna14, Nicholas J Johnson15, Michael J Lanspa16, Lynne D Richardson17, Kelly C Vranas18, Derek C Angus19, Rebecca M Baron20, Benjamin A Haaland21, Douglas L Hayden22, B Taylor Thompson23, Todd W Rice24, Catherine L Hough25.   

Abstract

BACKGROUND: Understanding COVID-19 epidemiology is crucial to clinical care and to clinical trial design and interpretation.
OBJECTIVE: To describe characteristics, treatment, and outcomes among patients hospitalized with COVID-19 early in the pandemic.
METHODS: A retrospective cohort study of consecutive adult patients with laboratory-confirmed, symptomatic SARS-CoV-2 infection admitted to 57 US hospitals from March 1 to April 1, 2020.
RESULTS: Of 1480 inpatients with COVID-19, median (IQR) age was 62.0 (49.4-72.9) years, 649 (43.9%) were female, and 822 of 1338 (61.4%) were non-White or Hispanic/Latino. Intensive care unit admission occurred in 575 patients (38.9%), mostly within 4 days of hospital presentation. Respiratory failure affected 583 patients (39.4%), including 284 (19.2%) within 24 hours of hospital presentation and 413 (27.9%) who received invasive mechanical ventilation. Median (IQR) hospital stay was 8 (5-15) days overall and 15 (9-24) days among intensive care unit patients. Hospital mortality was 17.7% (n = 262). Risk factors for hospital death identified by penalized multivariable regression included older age; male sex; comorbidity burden; symptoms-to-admission interval; hypotension; hypoxemia; and higher white blood cell count, creatinine level, respiratory rate, and heart rate. Of 1218 survivors, 221 (18.1%) required new respiratory support at discharge and 259 of 1153 (22.5%) admitted from home required new health care services.
CONCLUSIONS: In a geographically diverse early-pandemic COVID-19 cohort with complete hospital folllow-up, hospital mortality was associated with older age, comorbidity burden, and male sex. Intensive care unit admissions occurred early and were associated with protracted hospital stays. Survivors often required new health care services or respiratory support at discharge. ©2022 American Association of Critical-Care Nurses.

Entities:  

Mesh:

Year:  2022        PMID: 34709373      PMCID: PMC8891038          DOI: 10.4037/ajcc2022549

Source DB:  PubMed          Journal:  Am J Crit Care        ISSN: 1062-3264            Impact factor:   2.207


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8.  Characteristics, Outcomes, and Trends of Patients With COVID-19-Related Critical Illness at a Learning Health System in the United States.

Authors:  George L Anesi; Juliane Jablonski; Michael O Harhay; Joshua H Atkins; Jasmeet Bajaj; Cameron Baston; Patrick J Brennan; Christina L Candeloro; Lauren M Catalano; Maurizio F Cereda; John M Chandler; Jason D Christie; Tara Collins; Katherine R Courtright; Barry D Fuchs; Emily Gordon; John C Greenwood; Steven Gudowski; Asaf Hanish; C William Hanson; Monica Heuer; Paul Kinniry; Zev Noah Kornfield; Gregory B Kruse; Meghan Lane-Fall; Niels D Martin; Mark E Mikkelsen; Dan Negoianu; Jose L Pascual; Maulik B Patel; Steven C Pugliese; Zaffer A Qasim; John P Reilly; John Salmon; William D Schweickert; Michael J Scott; Michael G S Shashaty; Corinna P Sicoutris; John K Wang; Wei Wang; Arshad A Wani; Brian J Anderson; Jacob T Gutsche
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Review 9.  A minimal common outcome measure set for COVID-19 clinical research.

Authors: 
Journal:  Lancet Infect Dis       Date:  2020-06-12       Impact factor: 25.071

10.  Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial.

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4.  Factors Associated with ICU Admission in Patients with COVID-19: The GOL2DS Score.

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