Literature DB >> 3470667

Pill method failures.

M J Sparrow.   

Abstract

This is a study over a four year period from November 1981 to December 1985 documenting 163 cases of pill method failures in reliable pill takers. In over one third of these cases (36%) there were no predisposing factors. Significant factors which were associated with failure were diarrhoea and/or vomiting in 35%, and breakthrough bleeding on the combined pill in 21%. While there is controversy in the literature about the role of antibiotics in causing pill failure, this study found 23% of failures associated with antibiotic use. Two failures occurred on anticonvulsant medication. Recommendations are made for improved instructions to patients.

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Keywords:  Acceptor Characteristics; Acceptors; Age Factors; Antibiotics; Behavior; Biology; Bleeding; Clinical Research; Contraception; Contraception Failure; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive Methods--contraindications; Contraceptive Methods--side effects; Contraceptive Usage; Demographic Factors; Developed Countries; Developing Countries; Diarrhea; Diseases; Drugs; Family Planning; Family Planning Programs; Gastrointestinal Effects; Genital Effects, Female; Genitalia; Genitalia, Female; Menstruation Disorders; Metrorrhagia; Nausea; New Zealand; Oceania; Oral Contraceptives--contraindications; Oral Contraceptives--side effects; Physiology; Population; Population Characteristics; Research Methodology; Signs And Symptoms; Smoking; Social Behavior; Treatment; Urogenital Effects; Urogenital System; Vomiting

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Year:  1987        PMID: 3470667

Source DB:  PubMed          Journal:  N Z Med J        ISSN: 0028-8446


  7 in total

1.  Absence of pharmacokinetic interactions of the combined contraceptive vaginal ring NuvaRing with oral amoxicillin or doxycycline in two randomised trials.

Authors:  Peter Dogterom; Michiel W van den Heuvel; Torben Thomsen
Journal:  Clin Pharmacokinet       Date:  2005       Impact factor: 6.447

Review 2.  Pharmacokinetic drug interactions with oral contraceptives.

Authors:  D J Back; M L Orme
Journal:  Clin Pharmacokinet       Date:  1990-06       Impact factor: 6.447

3.  Antibiotic and oral contraceptive drug interactions: Is there a need for concern?

Authors:  G G Zhanel; S Siemens; K Slayter; L Mandell
Journal:  Can J Infect Dis       Date:  1999-11

Review 4.  Interactions between oral contraceptives and antifungals/antibacterials. Is contraceptive failure the result?

Authors:  E Weisberg
Journal:  Clin Pharmacokinet       Date:  1999-05       Impact factor: 6.447

Review 5.  Clinical pharmacokinetics of contraceptive steroids. An update.

Authors:  G M Shenfield; J M Griffin
Journal:  Clin Pharmacokinet       Date:  1991-01       Impact factor: 6.447

6.  No interaction between ciprofloxacin and an oral contraceptive.

Authors:  P C Scholten; R M Droppert; M G Zwinkels; H L Moesker; J J Nauta; I M Hoepelman
Journal:  Antimicrob Agents Chemother       Date:  1998-12       Impact factor: 5.191

Review 7.  Oral contraceptives. Are drug interactions of clinical significance?

Authors:  G M Shenfield
Journal:  Drug Saf       Date:  1993-07       Impact factor: 5.606

  7 in total

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