Literature DB >> 34706144

The first international roundtable on "organ donation after circulatory death by medical assistance in dying" demonstrates increasing incidence of successful patient-driven procedure.

Johannes Mulder1, Hans Sonneveld1, Andrew Healey2,3, Dirk Van Raemdonck4.   

Abstract

Entities:  

Keywords:  clinical research/practice; donors and donation: donation after circulatory death (DCD); health services and outcomes research; organ procurement; organ procurement and allocation; organ transplantation in general; primary care; quality of care / care delivery; quality of life (QOL)

Mesh:

Year:  2021        PMID: 34706144      PMCID: PMC9297969          DOI: 10.1111/ajt.16879

Source DB:  PubMed          Journal:  Am J Transplant        ISSN: 1600-6135            Impact factor:   9.369


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DISCLOSURE

The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation. To the Editor: Organ donation after MAiD (medical assistance in dying) is a procedure requested by patients wishing to do good with the diseased body that also led them to request MAiD. It is endorsed by Eurotransplant and Canadian Blood Services. The first international roundtable on “organ donation after VAD/MAiD/euthanasia” (ODE) took place during the 26th WONCA (world conference of family doctors) 2021 in the Netherlands. The procedure is of increasing importance to physicians involved in end‐of‐life care, mainly family doctors, and the organ donation and transplantation community. The objective was to identify and discuss global ODE practice, connecting involved physicians and search for consensus. The topics, invited participants, and regional ambiguities were identified in advance by literature review and national preconference meetings. Sixteen euthanasia and/or organ donation experts, from the eight countries where euthanasia is legal, participated in the roundtable. They presented their country's practice followed by plenary discussions. Euthanasia was defined as “the act, legally undertaken by a third party, with the explicit intention of ending the patient's life, at the patient's voluntary, competent request.” Historical associations preclude using the term “euthanasia” in Canada (MAiD: medical assistance in dying), Australia (VAD: voluntary assisted dying), and New Zealand (AD: assisted dying). As of 2021, MAiD is legal in 10 jurisdictions (eight countries). Global euthanasia incidence in 2020 was 17 261 patients, including 5280 (31%) nononcological patients, a basic factor for eligibility for ODE (Table 1). Classic ODE (MAiD and donation both taking place in hospital) is provided in the Netherlands, Canada (British Colombia, Ontario, Quebec), and Belgium, regulated by national guideline (the Netherlands‐2017), national guidance (Canada‐2019), and regional manuals (Belgium). , , Provided 41 times in 2020, ODE is becoming a significant donor organ source (>5%) in the performing countries. Studies demonstrate excellent multi‐organ donation results and transplant outcomes for kidneys, lungs, and livers. A different classification needs to be implemented in national registries, for example DCD‐V, for the total transplant results to become clear. ODE(H) introduction is expected this year in Australia, New Zealand, and Spain.
TABLE 1

Organ donation after MAiD

JurisdictionLegalization yearNational terminologyEuthanasia death 2020/% of total registered deathODEODEODEH
Total2020Total
The Netherlands2002Euthanasie6938/4.6%74 (2012–2020)113
Belgium2002Euthanasie2444/2.2%56 (2005–2020)3
Luxembourg2009Euthanasie25/<1%
Canada2015/2016Medical assistance in dying7595/2.5%97 (2016–2020)272
Australia/Victoria2017, enacted 2019Voluntary assisted dying224/<1%
Australia/Western Australia2019, enacted 2021Voluntary assisted dyingNA
Australia/Tasmania2021, enacted 2023Voluntary assisted dyingNA
Spain2021EutanasiaNA
New Zealand2021Assisted dyingNA
Colombia1997/2014Eutanasia35/<1%

Abbreviations: ODE, organ donation after euthanasia; ODEH, organ donation after euthanasia from home; NA, not applicable.

Organ donation after MAiD Abbreviations: ODE, organ donation after euthanasia; ODEH, organ donation after euthanasia from home; NA, not applicable. ODE with anesthesia initiated at home (ODEH) has occurred five times since 2017 in the Netherlands and Canada, by different modes. , These involve either single‐organ donation ODEH with MAiD provided at the home of the patient and then body transportation to the hospital or multi‐organ donation ODEH with MAiD protracted after anesthesia at the patient's home with subsequent transportation to the hospital followed by death and organ donation. A common factor was the MAiD‐patient‐driven development of ODE in the participating countries. Physicians are urged by their own patients to make ODE(H) possible. In most countries, healthcare professionals' reluctance to propagate the possibility and general familiarity was a limitation. Discussions about desirability revealed preferences for ODEH due to similarity with the private, more comfortable, MAiD procedure at the patient's home. However, patient values and regulations differ by country and participants agreed that all ODE(H) modes should be offered. Participants agreed that ODE(H) must remain a MAiD‐patient‐care‐driven process, with maximum adaptation of donation processes and minimal intrusion into end‐of‐life care.
  4 in total

1.  Organ donation after medical assistance in dying at home.

Authors:  Johannes Mulder; Johan P C Sonneveld
Journal:  CMAJ       Date:  2018-11-05       Impact factor: 8.262

2.  Lung donation after medical assistance in dying at home.

Authors:  Andrew Healey; Marcelo Cypel; Helen Pyle; Caitlin Mills; Jodie Heffren; David Katz; Justin Smith; Robert Teranishi; Susan Lavery; Janice Beitel; Janet MacLean; Dwight Prodger; Shaf Keshavjee; Jonathan C Yeung
Journal:  Am J Transplant       Date:  2020-09-10       Impact factor: 8.086

3.  Organ Donation after Medical Assistance in Dying - Canada's First Cases.

Authors:  Ian M Ball; Andrew Healey; Sean Keenan; Fran Priestap; John Basmaji; Kimia Honarmand; Jeanna Parsons Leigh; Sam Shemie; Prosanto Chaudhury; Jeffrey M Singh; Jeffrey Zaltzman; Stephen Beed; Matthew Weiss
Journal:  N Engl J Med       Date:  2020-02-06       Impact factor: 91.245

4.  [Guideline 'Organ donation following euthanasia"].

Authors:  H Mulder; G Olthuis; M Siebelink; R Gerritsen; E van Heurn
Journal:  Ned Tijdschr Geneeskd       Date:  2017
  4 in total
  1 in total

1.  Utility of Islet Cell Preparations From Donor Pancreases After Euthanasia.

Authors:  Diedert L De Paep; Freya Van Hulle; Zhidong Ling; Marian Vanhoeij; Robert Hilbrands; Wim Distelmans; Pieter Gillard; Bart Keymeulen; Daniel Pipeleers; Daniel Jacobs-Tulleneers-Thevissen
Journal:  Cell Transplant       Date:  2022 Jan-Dec       Impact factor: 4.139

  1 in total

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