Literature DB >> 34705172

Serum Serotonin as a Biomarker of the Efficacy of PAP-Therapy in Sleep Apnea Syndrome.

I M Madaeva1, O N Berdina2, E B Ukhinov2, N A Kurashova2, N V Semenova2, T A Bairova2, A V Bel'skikh2, L V Natyaganova2, S I Kolesnikov2, L I Kolesnikova2.   

Abstract

Serum serotonin levels were determined by HPLC in 30 patients with diagnosed obstructive sleep apnea syndrome before and after 3-month course of PAP-therapy and in 14 subjects without obstructive sleep apnea symptoms. It was found that elimination of hypoxic conditions was associated with an increase in serotonin level. The results demonstrate the effectiveness of PAP-therapy during sleep and allow assessing the role of serotonin as a potential biomarker of intermittent hypoxia during sleep.
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  apnea syndrome; biomarker; hypoxia; serotonin

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Year:  2021        PMID： 34705172     DOI： 10.1007/s10517-021-05301-5

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  7 in total

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Authors:  George B Richerson
Journal:  Nat Rev Neurosci       Date:  2004-06       Impact factor: 34.870

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Journal:  Lancet Respir Med       Date:  2019-07-09       Impact factor: 30.700

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Authors:  M J Thorpy
Journal:  J Clin Neurophysiol       Date:  1990-01       Impact factor: 2.177

5.  The effects of serotonin antagonists in an animal model of sleep-disordered breathing.

Authors:  S C Veasey; K A Panckeri; E A Hoffman; A I Pack; J C Hendricks
Journal:  Am J Respir Crit Care Med       Date:  1996-02       Impact factor: 21.405

6.  Incidence of Obstructive Sleep Apnea in Elderly Edentulous Patients and the Possible Correlation of Serum Serotonin and Apnea-Hypopnea Index.

Authors:  Arvind Tripathi; Soumyojeet Bagchi; Juhi Singh; Suryakant Tripathi; Narendra Kumar Gupta; Varun Arora
Journal:  J Prosthodont       Date:  2017-08-21       Impact factor: 2.752

Review 7.  Serotonin agonists and antagonists in obstructive sleep apnea: therapeutic potential.

Authors:  Sigrid C Veasey
Journal:  Am J Respir Med       Date:  2003
  7 in total

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