Gretchen Bandoli1, Denise Suttner2,3, Elizabeth Kiernan2, Rebecca J Baer2,4, Laura Jelliffe-Pawlowski4, Christina D Chambers2. 1. Department of Pediatrics, University of California San Diego, La Jolla California, San Diego, USA. gbandoli@health.ucsd.edu. 2. Department of Pediatrics, University of California San Diego, La Jolla California, San Diego, USA. 3. Rady Children's Hospital, San Diego, CA, USA. 4. Preterm Birth Initiative, University of California San Francisco, San Francisco, USA.
Abstract
OBJECTIVE: The objective was to investigate maternal and pregnancy characteristics associated with neonatal encephalopathy (NE). STUDY DESIGN: We queried an administrative birth cohort from California between 2011 and 2017 to determine the association between each factor and NE with and without hypothermia treatment. RESULTS: From 3 million infants born at 35 or more weeks of gestation, 6,857 cases of NE were identified (2.3 per 1000 births), 888 (13%) received therapeutic hypothermia. Risk factors for NE were stronger among cases receiving hypothermia therapy. Substance-related diagnosis, preexisting diabetes, preeclampsia, and any maternal infection were associated with a two-fold increase in risk. Maternal overweight/obesity, nulliparity, advanced maternal age, depression, gestational diabetes or hypertension, and short or long gestations also predicted NE. Young maternal age, Asian race and Hispanic ethnicity, and cannabis-related diagnosis lowered risk of NE. CONCLUSIONS: By disseminating these results, we encourage further interrogation of these perinatal factors.
OBJECTIVE: The objective was to investigate maternal and pregnancy characteristics associated with neonatal encephalopathy (NE). STUDY DESIGN: We queried an administrative birth cohort from California between 2011 and 2017 to determine the association between each factor and NE with and without hypothermia treatment. RESULTS: From 3 million infants born at 35 or more weeks of gestation, 6,857 cases of NE were identified (2.3 per 1000 births), 888 (13%) received therapeutic hypothermia. Risk factors for NE were stronger among cases receiving hypothermia therapy. Substance-related diagnosis, preexisting diabetes, preeclampsia, and any maternal infection were associated with a two-fold increase in risk. Maternal overweight/obesity, nulliparity, advanced maternal age, depression, gestational diabetes or hypertension, and short or long gestations also predicted NE. Young maternal age, Asian race and Hispanic ethnicity, and cannabis-related diagnosis lowered risk of NE. CONCLUSIONS: By disseminating these results, we encourage further interrogation of these perinatal factors.
Authors: R J Baer; E E Rogers; J C Partridge; J G Anderson; M Morris; M Kuppermann; L S Franck; L Rand; L L Jelliffe-Pawlowski Journal: J Perinatol Date: 2016-07-28 Impact factor: 2.521
Authors: Cally J Tann; Margaret Nakakeeto; Barbara A Willey; Margaret Sewegaba; Emily L Webb; Ibby Oke; Emmanuel Derek Mutuuza; Donald Peebles; Margaret Musoke; Kathryn A Harris; Neil J Sebire; Nigel Klein; Jennifer J Kurinczuk; Alison M Elliott; Nicola J Robertson Journal: Arch Dis Child Fetal Neonatal Ed Date: 2017-08-05 Impact factor: 5.747