Chromosomes in acute lymphocytic leukemia.

Results of chromosome analysis in acute lymphocytic leukemia are reviewed. Emphasis is placed on so-called specific translocations and their association with cytology, immunology, and prognosis. Data presently available suggest that chromosomes in acute lymphocytic leukemia are not only an important, independent prognostic factor, but also contribute to a new understanding of leukemic cell origin and pathway, which may enable us to overcome the limitations of present classification schemes.