COVID-19 ARDS: a review of imaging features and overview of mechanical ventilation and its complications.

The first cluster of cases of COVID-19 pneumonia was reported on December 31, 2019. Since then, this disease has spread rapidly across the world, and as of September 17, 2021, there are 226,844,344 cases of COVID-19 worldwide with 4,666,334 deaths related to COVID-19. While most COVID-19 cases are mild, some cases are severe with patients developing acute respiratory distress syndrome (ARDS). The pathophysiology of ARDS includes damage to the alveolar epithelium that leads to increased permeability of the alveolar epithelial barrier causing hyaline membrane formation, interstitial edema, and alveolar edema that results in severe hypoxia. Patients with COVID-19 ARDS are supported by non-invasive or invasive mechanical ventilation with an aim to improve oxygenation and maintain adequate blood oxygen levels. Increased intra-alveolar pressure while on mechanical ventilation may lead to alveolar rupture and thus barotrauma-related injuries such as lung tension cysts, pulmonary interstitial emphysema (PIE), pneumomediastinum, pneumopericardium, and pneumothorax. Recent studies have shown that the rate of barotrauma-related events is higher in patients with COVID-19 ARDS compared to patients with ARDS secondary to other etiologies. Radiologists should be aware of the imaging features of COVID-19 ARDS as well as the complications of mechanical ventilation. This educational manuscript will review the features of COVID-19 ARDS, discuss imaging of patients on mechanical ventilation, and review the imaging features of complications related to mechanical ventilation, including ventilator-associated lung injuries.

Introduction

COVID-19 (Corona Virus Disease 2019) is caused by the corona virus 2 (SARS-CoV-2) [1]. SARS CoV-2 virus gains entry into cells when its spike (S) protein binds to angiotensin converting enzyme 2 (ACE2) receptor [2, 3]. ACE2 is expressed on the epithelial surfaces of nasal mucosa, oral mucosa, and lungs [2]. The virus causes respiratory infections due to its predilection to involve the lungs [3]. COVID-19 infections are mild in the majority (81%) of the cases; severe disease with hypoxia, dyspnea, involving > 50% of lung on CT is seen in 14% of patients; and critical disease with respiratory failure, shock, and multiorgan failure is seen in 5% of cases [4, 5]. The rate of critical disease is higher in hospitalized patients with frequencies ranging from 24 to 42% [6, 7]. Some studies have shown that as high as 42% of patients with COVID-19 pneumonia could develop acute respiratory distress syndrome (ARDS) with median time to intubation of 8.5 days from the onset of symptoms [7, 8]. COVID-19 ARDS has a worse outcome compared to ARDS related to other conditions with mortality rates ranging from 65.7 to 94% in patients who require mechanical ventilation [7, 8].

In this article, we describe the clinicopathological and radiological findings of COVID-19 ARDS, discuss imaging of patients on mechanical ventilation, and review the imaging features of complications related to mechanical ventilation, including ventilator-related lung injuries.

COVID-19 ARDS

COVID-19 ARDS is diagnosed when a patient with confirmed COVID-19 infection develops acute respiratory distress meeting the Berlin 2012 ARDS diagnostic criteria which include (i) acute hypoxemic respiratory failure (ii) developing within 1 week of onset of symptoms (iii) with bilateral air space opacities on X-ray, CT (computed tomography) or ultrasound of the chest (iv) not explained by cardiac failure or fluid overload [9]. COVID-19 ARDS has a slight delay in onset ranging from 8 to 12 days compared to ARDS from other causes where the onset is within 7 days [10]. The lung compliance is normal or high in some patients with COVID-19 ARDS unlike ARDS from the other causes [10]. The main cause of COVID-19 ARDS is damage to alveolar epithelial cells resulting in hyaline membrane formation in the initial stages, followed by interstitial edema and fibroblast proliferation [10, 11]. Imaging studies performed at the time of admission can help in risk stratification of patients with COVID-19 [12]. If diagnosis of ARDS is made at the time of admission, the patient can be directed for intensive care unit (ICU) admission versus in the absence of ARDS patient can be admitted to COVID-19 floor and monitored [12]. Imaging can also help in identifying complications of COVID-19 such as pulmonary embolism, aortic thrombus, and complications arising from mechanical ventilation such as pneumomediastinum, pneumothorax, and superimposed pneumonia [12].

Imaging features of COVID-19 ARDS

CT findings of COVID-19 pneumonia have been classified as typical, atypical, and indeterminate by Radiological Society of North America (RSNA) expert consensus [13]. Several prior studies have described radiological features of COVID-19, their variation over a period of time, and patient outcomes based on imaging features at the time of presentation [14-17]. We are providing a short summary of the radiological features of COVID-19 pneumonia for the convenience of readers. Imaging features of COVID-19 are classified as typical, which include peripheral ground glass opacities and/or consolidation, peripheral nodular opacities resembling organizing pneumonia, and crazy paving appearance characterized by ground glass opacities with thickened inter and intralobular septae (Fig. 1). Indeterminate imaging features include peribronchial ground glass opacities, and diffuse ground glass opacities (Fig. 2). Atypical imaging features include tree-in-bud opacities, pleural effusions and smooth interlobular septal thickening resembling pulmonary edema, lobar consolidation, and cavitary lesions raising suspicion for other conditions (Fig. 3).

Fig. 1

Chest CT findings showing typical imaging features of COVID-19 pneumonia. A—Axial non-contrast chest CT image in a 48-year-old man with COVID-19 pneumonia demonstrates peripheral ground glass opacities in the bilateral lungs (arrows). B—Axial contrast-enhanced chest CT image in a 68-year-old man with COVID-19 pneumonia shows bilateral peripheral nodular ground glass opacities (arrows). C—Axial contrast-enhanced chest CT image in a 72-year-old woman with COVID-19 pneumonia reveals ground glass opacities in the bilateral lungs with inter- and intralobular septal thickening with a crazy paving appearance

Fig. 2

Chest CT findings showing indeterminate imaging features of COVID-19 pneumonia. A—Axial contrast-enhanced chest CT image in a 38-year-old man with COVID-19 pneumonia shows bilateral peribronchovascular ground glass opacities (white arrows). B—Axial contrast-enhanced chest CT image in a 60-year-old man with COVID-19 pneumonia reveals diffuse bilateral ground glass opacities

Fig. 3

Chest CT findings showing atypical imaging features of COVID-19 pneumonia. A—Axial contrast-enhanced chest image in a 72-year-old man with RT-PCR test positive for COVID-19 demonstrates clusters of tree-in-bud nodules in the right middle lobe (arrows). B—Contrast-enhanced Axial chest CT image in a 58-year-old man with RT-PCR test positive for COVID-19 reveals a mass-like consolidation in the right lower lobe with a central area of lucency, consistent with a cavitation (arrow). C—Axial contrast-enhanced chest CT image in a 53-year-old man with RT-PCR test positive for COVID-19 shows small bilateral pleural effusions with mild interlobular septal thickening resembling pulmonary edema. D—Axial contrast-enhanced chest CT image in a 66-year-old man with positive RT-PCR for COVID-19 demonstrates consolidation in the left lower lobe (arrow)

The imaging features of COVID-19 ARDS are similar to ARDS from other etiologies. On chest x-ray, rapid progression of bilateral air space opacities within 7–12 days after the onset on COVID-19 should raise the suspicion for ARDS. There is lower lobe predominance of the air space opacities (Fig. 4) [18]. Similarly, on chest CT rapid progression of lung opacities which involve all 5 lobes in a patient with COVID-19 should also increase the concern for ARDS. Chest CT findings are characterized by anteroposterior gradient of lung opacities [19]. In the acute phase, there is a predilection for dense consolidation to involve the dependent posterior lower lobes with relative sparing of the anterior or non-dependent areas (Fig. 5) [19]. Therefore, prone positioning is thought to be beneficial in these patients to aid in alveolar recruitment and improve lung oxygenation [20, 21].

Fig. 4

Serial frontal (AP) chest x-rays in a 64-year-old man showing rapid progression of COVID-19 ARDS A—Initial chest x-ray with faint airspace opacities in the right lower lung (arrow). B—Chest x-ray 2 days later shows increase in the airspace opacities in the right lower lung (white arrow) and retrocardiac opacity. C—Chest x-ray 2 days later (4 days from the initial exam) shows rapid progression of bilateral airspace opacities with a lower lobe predominance and near complete opacification of both the lungs. Also note that the patient is intubated and the presence of a right-sided infusion port

Fig. 5

Axial non-contrast images (A, B, & C) of the chest CT in a 68-year-old man with COVID-19 pneumonia demonstrate bilateral lung opacities with anteroposterior density gradient. Dense consolidations are seen in the most dependent portion of the lungs (arrows) with relative sparing of the more anterior portion of the lungs. While nonspecific, these findings favor COVID-19 ARDS. An endotracheal tube nasogastric tube are also present

When interpreting chest x-rays in these patients, it is important to be aware of when they are imaged in the prone position, as this may artificially cause their air space opacities to appear different when compared with a supine chest x-ray (Fig. 6). Bronchial dilatation can be seen in the non-dependent portion of the lungs.

Fig. 6

Frontal chest radiographs in a 64-year-old man with COVID-19 ARDS. A—Supine image of the chest shows dense consolidation in the left lower lung (arrow). B—Image of the chest acquired in prone position in the same patient within two hours demonstrates apparent improvement of consolidations in the left lower lung (arrow) which is positional. A right internal jugular central venous catheter is present

Fibrotic lung changes are seen in some survivors of ARDS with the development of coarse reticulations and traction bronchiectasis in the anterior or non-dependent lungs while the posterior or dependent portions of the lungs are relatively preserved. Therefore, the presence of consolidation seems to protect against later development of fibrosis in patients with ARDS (Fig. 7) [19]. It is important to mention that one must be cautious when interpreting CT images on these patients not to overcall fibrosis while air space opacities are still present since this may have treatment and prognostic indications. Often times what may resemble fibrosis and traction bronchiectasis could potentially be reversible once the air space opacities have resolved. The pathophysiology and features of COVID-19 ARDS are still being studied and its long-term sequelae are yet to be identified.

Fig. 7

Axial non-contrast chest CT images in a 44-year-old man with COVID-19 ARDS showing progressive development of fibrosis in the upper lobes with relative sparing of lower lobes. A and B—Initial CT images, show COVID-19 ARDS with dependent consolidations in the bilateral lungs (arrows) and relative sparing of the upper lobes. C and D—CT images from nine months later, show new fibrotic changes with traction bronchiectasis in the bilateral upper lobes (arrows) with improvement of bilateral lower lobe consolidations. E and F—CT images eight months later and one year 4 months from initial CT, show peripheral and peribronchial ground glass opacities and consolidations in the upper lobes with traction bronchiectasis (arrows). Lower lobes are spared from fibrotic changes showing that consolidations during ARDS are protective against the subsequent development of lung fibrosis

Management of COVID-19 ARDS

Low flow nasal oxygen (< 6L/ min), high flow nasal oxygen (10–20L/min), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BPAP) are some of the non-invasive techniques used in patients with COVID-19 ARDS that are aimed at improving blood oxygenation while maintaining appropriate SpO2 levels [22, 23]. Frequent monitoring of these patients with clinical examination and arterial blood gas evaluation should be carried out every one to two hours. Intubation and mechanical ventilation should be considered when any of the following occur: (i) rapid progression of hypoxemia (ii) no improvement after high flow oxygen administration at 50L/min (iii) increased work of breathing, worsening mental status, hypercapnia, increased tidal volume (iv) hemodynamic instability or multiorgan failure [24].

Imaging of patients on mechanical ventilation

Patients on mechanical ventilation are imaged frequently with chest x-ray, mostly using portable technique at bedside. Imaging helps identify any malpositioned lines and tubes, assessing changes in air space opacities (progression, improvement, or stability), identifying acute superimposed conditions such as volume overload or bacterial infections, and diagnosing ventilator-related complications. Either before these patients require intubation or once they are weaned from the ventilator, it is important to know that it possible to perform chest radiographs with social distancing (at 6 feet) acquiring the images through the glass of the patient’s room while maintaining image quality and also preserving personal protective equipment (PPE) [25].

Ventilator-associated lung injury

Recent study by McGuinness et al. has demonstrated that patients with invasive mechanical ventilation for COVID-19 ARDS had higher rate of barotrauma (15%) compared to non-COVID-19 related ARDS (0.5%) during the same time period [26]. Mechanical ventilation causes increased pressure in the alveoli with subsequent disruption of their wall. Barotrauma-related findings include lung tension cysts, pneumomediastinum, pneumopericardium, pulmonary interstitial emphysema (PIE), and pneumothorax. We will review and discuss the imaging features of these entities which can be encountered with ventilator-associated lung injury.

Lung tension cysts

Lung tension cysts are usually most prominent at the subpleural surfaces and result from rupture of the weaker alveoli along the vessels and interlobular septa [27]. Tension cysts are difficult to identify by chest x-ray. On chest CT, they appear as thin-walled, lucent air-filled spaces more predominant in the anterior part of the upper and middle lobes (Fig. 8A).

Fig. 8

A—Lung tension cysts. A—Axial non-contrast chest CT image in a 78-year-old man with COVID-19 pneumonia on mechanical ventilation shows cavitary lesion/lung tension cyst in the subpleural right lower lobe (arrow). B—Pulmonary interstitial emphysema. Non-contrast axial chest CT image in a 45-year-old man with COVID-19 ARDS on mechanical ventilation shows pulmonary interstitial emphysema (PIE). Note the linear lucency surrounding bronchi/ pulmonary artery which is consistent with PIE (black arrows). Air is seen anteriorly consistent with pneumomediastinum (white arrow). Also seen are dependent consolidative opacities in the posterior lower lobes consistent with COVID-19 ARDS (arrowheads)

Pulmonary interstitial emphysema

Increased alveolar pressure results in rupture of alveoli with tracking of air along the interstitium, peribronchial tissues, and pulmonary perivascular sheaths [28]. Due to their decreased sensitivity compared with CT, chest x-rays have limited role in identifying PIE. Cystic or reticular lucencies can be seen in the interstitium radiating from the hilum in some cases. Concomitant pneumothorax or pneumomediastinum can sometimes be seen with chest x-ray. On chest CT, linear or dot-like radiolucent air is identified along the bronchi or pulmonary arteries (Fig. 8B). Reducing the ventilator pressures is the first step towards management of PIE. Pneumothorax and pneumomediastinum can be identified concomitantly.

Pneumomediastinum and pneumopericardium

Pneumomediastinum has been identified as the most common barotrauma-related event in patients with mechanical ventilation for COVID-19 ARDS [26]. Pneumomediastinum occurs secondary to alveolar rupture with backtracking of air through the interstitium in the peribronchial and perivascular sheaths into the hilum and eventually into the mediastinum, a phenomenon which has been described as Macklin effect [27, 29, 30]. Pneumomediastinum can be identified on chest x-ray by radiolucent air surrounding the normal anatomic structures within the mediastinum. The most common finding of pneumomediastinum is abnormal linear lucency along the left heart border on frontal chest x-ray (Fig. 9) [31]. Air can track from the mediastinum into the neck with development of subcutaneous emphysema. Other signs of pneumomediastinum on chest x-ray are described in Table 1 [31, 32].

Fig. 9

AP chest radiographs showing pneumomediastinum. A—AP chest radiograph in a 72-year-old male patient with COVID-19 ARDS on mechanical ventilation shows lucency surrounding the heart consistent with pneumomediastinum (arrows). B—AP chest radiograph in a 68-year-old man with COVID-19 ARDS on mechanical ventilation shows lucency adjacent to the left heart border (white arrow) and air outlining the lateral aspect of the left subclavian artery (black arrow) consistent with pneumomediastinum. An endotracheal tube, nasogastric tube, and right internal jugular central venous catheter are present

Table 1

Imaging features of complications of barotrauma

Complications of barotrauma	Imaging features of complications of barotrauma
Lung tension cysts	• Subpleural cysts with a predilection for the upper lobes and right middle lobe
Pulmonary interstitial emphysema	• Cystic or reticular lucencies in the interstitium radiating from the hilum • Linear or dot-like radiolucent air along the bronchi or pulmonary arteries on CT
Pneumomediastinum	• Ring around the artery sign—air surrounding pulmonary artery or its main branches • Tubular ring sign—air surrounding major branches of the aorta therefore outlining both sides of the great vessels • Double bronchial wall sign—air adjacent to the bronchus creates clear depiction of the bronchial wall • Continuous diaphragm sign—air posterior to the pericardium creates continuous contour of the diaphragm • Extrapleural sign—air extends between the parietal pleura and diaphragm • Pneumopericardium—air in the anterior pericardium • Thymic sail sign—elevation of thymus due to air in mediastinum • Subcutaneous emphysema in the neck
Pneumothorax	• Thin sharp pleural line with no lung markings beyond the line

On chest CT, pneumomediastinum is visualized as gas outlining the structures within the mediastinum. Air extending into extrapleural space can be differentiated from pneumothorax by the presence of thin connective tissue webs (Fig. 10) [32].

Fig. 10

Axial non-contrast chest CT images in a 72-year-old man with COVID-19 ARDS following mechanical ventilation with pneumomediastinum. A—Air with stranding in the anterior mediastinum consistent with pneumomediastinum (white arrow). Also note small left pneumothorax (black arrow). B—Air with stranding in the anterior mediastinum consistent with pneumomediastinum. Bilateral ground glass and consolidative opacities are consistent with known COVID-19 ARDS

The mechanism of development of pneumopericardium is similar to pneumomediastinum. Isolated pneumopericardium rarely occurs due to mechanical ventilation and is often accompanied by pneumomediastinum [33]. Stretching of medial pleura by the pneumopericardium results in pneumothorax due to rupture of the pleura. On chest x-ray, air outlines the pericardium as a single band of gas more prominent adjacent to the left ventricle and right atrium, contrary to pneumomediastinum which presents as multiple lucencies of gas in the mediastinum. In pneumopericardium, the gas does not extend into the upper mediastinum and is sharply marginated by the pericardial sac. Pneumomediastinum is self-limited and resolves when ventilatory pressures are reduced. In rare cases when pneumomediastinum is very large, mediastinotomy is performed and a mediastinal drain is placed [34].

Pneumothorax

Pneumothorax is the second most commonly identified complication of mechanical ventilation in COVID-19 ARDS accounting for 9% of barotrauma-related events [26, 35]. In a patient on mechanical ventilation, pneumothorax develops when alveolar pressure increases resulting in rupture of alveoli with air backtracking along the pulmonary interstitium, peribronchial sheaths, perivascular sheaths, and eventually into the pleural space [27]. Chest x-ray is readily available to image patients on ventilators and has high specificity for diagnosing pneumothorax, as high as 99% [36]. However, the sensitivity of chest x-ray in identifying pneumothorax can be as low as 38% making it imperative for radiologists to be familiar with all variable radiological appearances of pneumothorax [37]. In the supine position, air commonly rises to the anteromedial pleural space which is the least dependent region and outlines the structures of mediastinum [36]. In the suprahilar region, air outlines the superior vena cava, azygous vein, anterior junction line, and left subclavian vein. In the infrahilar region, air outlines inferior vena cava, heart border, diaphragm under the heart, pericardial fat pad, superior pulmonary vein and causes a medial anterior deep cardiophrenic sulcus [36]. Air accumulating in the subpulmonic space presents with a lateral deep costophrenic sulcus (known as the deep sulcus sign), sharp diaphragmatic outlines, and increased lucency overlying the upper abdomen [36]. When air rises apicolaterally, the visceral pleural line is commonly seen and there is lucency peripheral to the line containing no lung markings [36]. Posteromedial pneumothorax presents as a triangle at the medial costophrenic sulcus with the apex directed towards the hilum [36].

Pneumothorax can be easily identified on lung windows though CT is not routinely recommended as the first modality for the diagnosis of pneumothorax. CT features of pneumothorax are similar to chest x-ray findings with radiolucent air in the pleural space. First-line treatment for patients with pneumothorax is immediate reduction of ventilator pressures and eventually placement of a chest tube if the pneumothorax is large enough or worsens.

Tension pneumothorax occurs when a pneumothorax increases to the point of causing increased intrathoracic pressure, which limits systemic venous return and decreases cardiac output. Tension pneumothorax is rarely encountered in ARDS because the lungs are stiff, which limits its collapse. While the diagnosis of tension pneumothorax is a clinical one, findings which are highly suggestive on chest x-ray include a large amount of air in the pleural space with contralateral displacement of the heart and mediastinal structures, ipsilateral flattening or inversion of the diaphragm, and lung collapse (Fig. 11). Tension pneumothorax is a life-threatening condition requiring immediate intervention with chest tube placement or needle decompression.

Fig. 11

A—AP Chest x-ray in a 65-year-old man with COVID-19 ARDS on mechanical ventilation shows lucency in the right pleural space consistent with pneumothorax (arrow). A chest tube is present as well. B—Axial contrast-enhanced chest CT image in the same patient shows right pneumothorax (arrow) with chest tube. C—Coronal non-contrast chest CT image in a 55-year-old man with COVID-19 ARDS on mechanical ventilation shows large right tension pneumothorax with collapse of the right lung (arrowhead), with deviation of the heart and mediastinum to the contralateral side (thick arrow) and flattening of the right hemidiaphragm (thin arrow). A tracheostomy tube is also present in A & C

Ventilator-associated pneumonia

Prolonged hospital stay in COVID-19 patients with mechanical ventilation increases their risk for hospital-acquired infections, particularly ventilator-associated pneumonia (VAP). Diagnosis of VAP is challenging in COVID-19 patients because the clinical features of VAP overlap with worsening COVID-19 pneumonia [38, 39]. Microbiological cultures of deep respiratory secretions or endotracheal aspirate are diagnostic for VAP. The role of imaging remains critical in this scenario. Patients on mechanical ventilation are monitored frequently with chest x-rays. Sudden increase in airspace opacities in COVID-19 patients should raise the suspicion for VAP in patients who are rapidly deteriorating. Chest CT is performed in cases when a patient is clinically deteriorating but the chest x-ray findings are equivocal or stable. Chest CT findings include new superimposed lobar consolidative opacities, increased bilateral consolidative opacities, and/or centrilobular nodules (Fig. 12).

Fig. 12

A and B—Initial axial non-contrast chest CT images in a 68-year-old man show ground glass opacities in the left upper lobe and bilateral lower lobes concerning for COVID-19 pneumonia. The patient subsequently developed COVID-19 ARDS and was supported with mechanical ventilation. Axial contrast-enhanced CT images (C and D) were obtained two months later when the patient had increasing secretions and worsening fever. There are new consolidations in the right upper lobe (arrow) and worsening ground glass opacities in the lower lobes. Cultures from the endotracheal tube secretions were positive for Klebsiella pneumoniae and Streptococcus pneumoniae, consistent with ventilator associated pneumonia (VAP)

Ventilated patients are also at increased risk of aspiration. Aspiration should be suspected on chest x-ray when there are new or worsening opacities in the lower lobes, commonly seen in the retrocardiac and infrahilar regions. On chest CT, superimposed aspiration is best recognized by centrilobular nodules or consolidative opacities in the dependent parts of the lungs (usually most pronounced in the lower lobes, but can also involve the upper lobes or right middle lobe) when the patient is in the supine position. In patients who are in the prone position, the tree-in-bud/ centrilobular nodules or consolidations can be seen in bilateral upper lobes and right middle lobe. CT can also demonstrate secretions in the trachea and bronchi in patients with aspiration, as well as a dilated, fluid-filled esophagus or a hiatal hernia, which places the patient at increased risk for aspiration.

Tracheal injury during intubation

Iatrogenic rupture of the trachea during intubation is extremely rare with an incidence of approximately 0.005% [40]. The most common site of injury is the posterior membranous wall at the cervical level. The right posterolateral wall is the most common site of injury due to lack of support from the esophagus in this location. Imaging findings on chest radiograph include pneumomediastinum and subcutaneous emphysema in the neck and upper thorax. Findings on CT include the presence of a tracheal diverticulum seen as a small outpouching, most commonly along the right posterolateral wall of the trachea at the level of the thoracic inlet; however, these are much more commonly seen as an incidental finding in patients without history of tracheal injury. Severe cases of tracheal rupture present with discontinuity in the posterior tracheal wall with associated extensive pneumomediastinum, pneumothorax, and subcutaneous emphysema (Fig. 13).

Fig. 13

Axial non-contrast chest CT images in a 94-year old man with tracheal rupture secondary to traumatic intubation. A—There is rupture of the right posterior wall of the trachea (white arrow) with subcutaneous emphysema in the right anterior chest wall (black arrow). B—Extensive pneumomediastinum (white arrow) and right anterior chest wall emphysema (black arrow) are also seen. Bilateral consolidative opacities (arrowheads) are also present consistent with COVID-19 ARDS

Conclusion

COVID-19 ARDS results from injury to the alveolar epithelial cells and endothelium resulting in hyaline membrane formation, and accumulation of fluid in the alveolar spaces that results in hypoxemia. Mechanical ventilation is required as a supportive measure in the majority of patients with ARDS. Patients on mechanical ventilation are prone to complications including barotrauma with alveolar rupture and superimposed bacterial pneumonia. Patients with COVID-19 ARDS, as well as patients who are on mechanical ventilation, are imaged frequently; therefore, radiologists play a pivotal role in early and accurate diagnosis. Radiologists should be aware of the imaging features of COVID-19 ARDS and complications of mechanical ventilation, and be ready to alert the clinician when acute, life-threatening ones are present.