Wolf Petersen1, Mats Bentzin2, Sebastian Bierke2, Hi Un Park2, Martin Häner2. 1. Klinik Für Orthopädie Und Unfallchirurgie, Martin Luther Hospital, Caspar-Theyß-Straße 27-31, Grunewald, 14193, Berlin, Germany. wolf.petersen@jsd.de. 2. Klinik Für Orthopädie Und Unfallchirurgie, Martin Luther Hospital, Caspar-Theyß-Straße 27-31, Grunewald, 14193, Berlin, Germany.
Abstract
PURPOSE: Aim of this study was to evaluate the effect of tranexamic acid (TXA) on the outcome after medial open wedge osteotomy. MATERIAL AND METHODS: A prospective non-randomized comparative study with 52 patients has been performed. In both treatment groups, the same surgical technique for the medial open wedge HTO was used. In group 1 (N: 26) the patients received 1 g TXA i.v. preoperatively, in group 2 (N: 26) no TXA was given. Primary outcome measure was the decrease in hemoglobin concentration. Secondary outcome criteria were postoperative pain, intraarticular effusion (measured by ultrasound), range of motion (ROM) at discharge, peri- and postoperative complications and the KOOS PS (pre- and postoperatively at 1 year follow up). RESULTS: Hemoglobin decrease was significantly less in the TXA group compared to the non TXA group. Postoperative pain and intraarticular effusion was also significantly lower and ROM at discharge was higher in the TXA group. There was no group difference in peri- and postoperative complications and the pre- and postoperatively KOOS PS. CONCLUSIONS: The results of the present study show the systemic application of 1 g TXA reduces hemoglobin drop and postoperative morbidity (pain, intraarticular effusion, and ROM) after tibial open wedge HTO.
PURPOSE: Aim of this study was to evaluate the effect of tranexamic acid (TXA) on the outcome after medial open wedge osteotomy. MATERIAL AND METHODS: A prospective non-randomized comparative study with 52 patients has been performed. In both treatment groups, the same surgical technique for the medial open wedge HTO was used. In group 1 (N: 26) the patients received 1 g TXA i.v. preoperatively, in group 2 (N: 26) no TXA was given. Primary outcome measure was the decrease in hemoglobin concentration. Secondary outcome criteria were postoperative pain, intraarticular effusion (measured by ultrasound), range of motion (ROM) at discharge, peri- and postoperative complications and the KOOS PS (pre- and postoperatively at 1 year follow up). RESULTS: Hemoglobin decrease was significantly less in the TXA group compared to the non TXA group. Postoperative pain and intraarticular effusion was also significantly lower and ROM at discharge was higher in the TXA group. There was no group difference in peri- and postoperative complications and the pre- and postoperatively KOOS PS. CONCLUSIONS: The results of the present study show the systemic application of 1 g TXA reduces hemoglobin drop and postoperative morbidity (pain, intraarticular effusion, and ROM) after tibial open wedge HTO.
Authors: Stephanie Floerkemeier; Alex E Staubli; Steffen Schroeter; Sabine Goldhahn; Philipp Lobenhoffer Journal: Int Orthop Date: 2014-01 Impact factor: 3.075
Authors: Philipp Schuster; Markus Geßlein; Michael Schlumberger; Philipp Mayer; Raul Mayr; Damian Oremek; Sebastian Frank; Martin Schulz-Jahrsdörfer; Jörg Richter Journal: Am J Sports Med Date: 2018-03-28 Impact factor: 6.202
Authors: Paul Wallace; Andrew Haines; Robert Harrison; Julie A Barber; Simon Thompson; Jennifer Roberts; Paul B Jacklin; Leo Lewis; Paul Wainwright Journal: BMC Fam Pract Date: 2002-01-11 Impact factor: 2.497
Authors: Siri B Winther; Olav A Foss; Tina S Wik; Shawn P Davis; Monika Engdal; Vigleik Jessen; Otto S Husby Journal: Acta Orthop Date: 2014-09-01 Impact factor: 3.717
Authors: Sebastian Bierke; Martin Häner; Mats Bentzin; Hi Un Park; Wolf Petersen Journal: Knee Surg Sports Traumatol Arthrosc Date: 2022-03-27 Impact factor: 4.342
Authors: Alexander M Crawford; Harry M Lightsey; Grace X Xiong; Brendan M Striano; Andrew J Schoenfeld; Andrew K Simpson Journal: Arch Orthop Trauma Surg Date: 2021-04-18 Impact factor: 2.928