Silviu Guler-Margaritis1,2, Adriana Mercan-Stanciu1,3, Letitia Toma1,3, Daniel Rusie4, Teodora Isac1,3, Mihai Dodot1,3, Anca Zgura1,5, Nicolae Bacalbasa1, Bogdan Haineala1,2, Dumitru Cristinel Badiu6,7, Dragos Serban1,8, Elena Laura Iliescu1,3. 1. Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. 2. Department of Urology, Fundeni Clinical Institute, Bucharest, Romania. 3. Department of Internal Medicine II, Fundeni Clinical Institute, Bucharest, Romania. 4. Department of General Surgery, Clinical Emergency Hospital, Bucharest, Romania. 5. Department of Oncology-Radiotherapy, "Prof Dr Alexandru Trestioreanu" Institute of Oncology, Bucharest, Romania. 6. Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; doctorcristianbadiu@yahoo.com. 7. General Surgery Department, Bagdasar Arseni Clinical Emergency Hospital, Bucharest, Romania. 8. Department of Surgery, University Emergency Hospital, Bucharest, Romania.
Abstract
BACKGROUND/AIM: Liver injury has been frequently reported in association with SARS-CoV-2 infection, but data are still lacking regarding the impact of pre-existing liver damage and neoplasia on SARS-CoV-2 infection outcome and vice-versa. This study aimed to assess the effects of SARS-CoV-2 infection on hepatocellular carcinoma (HCC) in chronic hepatitis C virus (HCV) infected patients, both in therapeutic-naïve and patients treated with direct acting antivirals. PATIENTS AND METHODS: We conducted a retrospective cohort study on 21 patients with a personal history of HCV infection, that have been diagnosed with different forms of HCC and who were subsequently infected with SARS-CoV-2. Patients were monitored by liver function tests, tumoral markers, blood cell count, and coagulation profile periodically. RESULTS: Solitary HCC nodules were predominant among the subjects who achieved sustained virologic response, while multinodular and infiltrative patterns were mostly prevalent among the treatment-naïve group. Most patients had mild and moderate COVID-19 infections. CONCLUSION: Within the current global pandemic crisis, cancer patients are highly vulnerable and in need of constant monitoring. Among patients with HCC, the ones with cured HCV infection may be at a lower risk of fatality than those with active HCV infection, when diagnosed with SARS-CoV-2 infection.
BACKGROUND/AIM: Liver injury has been frequently reported in association with SARS-CoV-2 infection, but data are still lacking regarding the impact of pre-existing liver damage and neoplasia on SARS-CoV-2 infection outcome and vice-versa. This study aimed to assess the effects of SARS-CoV-2 infection on hepatocellular carcinoma (HCC) in chronic hepatitis C virus (HCV) infected patients, both in therapeutic-naïve and patients treated with direct acting antivirals. PATIENTS AND METHODS: We conducted a retrospective cohort study on 21 patients with a personal history of HCV infection, that have been diagnosed with different forms of HCC and who were subsequently infected with SARS-CoV-2. Patients were monitored by liver function tests, tumoral markers, blood cell count, and coagulation profile periodically. RESULTS: Solitary HCC nodules were predominant among the subjects who achieved sustained virologic response, while multinodular and infiltrative patterns were mostly prevalent among the treatment-naïve group. Most patients had mild and moderate COVID-19 infections. CONCLUSION: Within the current global pandemic crisis, cancer patients are highly vulnerable and in need of constant monitoring. Among patients with HCC, the ones with cured HCV infection may be at a lower risk of fatality than those with active HCV infection, when diagnosed with SARS-CoV-2 infection.
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