Tulin Ozturk1, Ecem Zeynep Kain2, Mete Bora Tuzuner3, Ayca Diren4, Sebnem Batur2, Hulya Yilmaz-Aydogan5, Oguz Ozturk5, Turgay Isbir6. 1. Department of Pathology, Cerrahpasa Medical School, Istanbul University Cerrahpasa, Istanbul, Turkey; dr.tulinozturk@gmail.com. 2. Department of Pathology, Cerrahpasa Medical School, Istanbul University Cerrahpasa, Istanbul, Turkey. 3. Research and Development Center, Acibadem Labmed Medical Laboratories, Istanbul, Turkey. 4. Department of Research and Development, Elips Healthcare Products, Istanbul, Turkey. 5. Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey. 6. Department of Medical Biology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
Abstract
BACKGROUND: Expression of kallikrein-11 (KLK11) has been found to be related to the prognosis of various human cancer types but its physiological functions in the steps of breast cancer (BC) progression are still unknown. MATERIALS AND METHODS: BC and adjacent normal breast tissue samples were collected from 28 patients. KLK11 expression levels were determined by real-time polymerase chain reaction for each sample and associations with known prognostic features were statistically analyzed. RESULTS: Although there was slight up-regulation in tumor tissues overall, significant down-regulation of KLK11 expression in tumor tissue was observed in the elderly and in patients with perineural invasion. Furthermore, tumor size, grade, mitotic score, necrosis, calcification, lymphatic invasion, hormone receptor status and Ki67 expression were associated with altered KLK11 level. CONCLUSION: Changes in expression levels of KLK11, associated with patient characteristics, might be used as complementary data in order to predict clinical outcome and prognosis in BC.
BACKGROUND: Expression of kallikrein-11 (KLK11) has been found to be related to the prognosis of various human cancer types but its physiological functions in the steps of breast cancer (BC) progression are still unknown. MATERIALS AND METHODS: BC and adjacent normal breast tissue samples were collected from 28 patients. KLK11 expression levels were determined by real-time polymerase chain reaction for each sample and associations with known prognostic features were statistically analyzed. RESULTS: Although there was slight up-regulation in tumor tissues overall, significant down-regulation of KLK11 expression in tumor tissue was observed in the elderly and in patients with perineural invasion. Furthermore, tumor size, grade, mitotic score, necrosis, calcification, lymphatic invasion, hormone receptor status and Ki67 expression were associated with altered KLK11 level. CONCLUSION: Changes in expression levels of KLK11, associated with patient characteristics, might be used as complementary data in order to predict clinical outcome and prognosis in BC.
Authors: David L Kolin; Keiyan Sy; Fabio Rotondo; Mena N Bassily; Kalman Kovacs; Christine Brezden-Masley; Catherine J Streutker; George M Yousef Journal: Tumour Biol Date: 2015-07-30