Acute cerebral infarction combined with a thyroid storm in a patient with both Moyamoya syndrome and Graves' disease.

Moyamoya syndrome (MMS) associated with hyperthyroidism, such as Graves' disease, is a rare condition that causes ischemic stroke with thyrotoxicity. A 43-year-old woman with symptoms of right hemiparesis was admitted. Brain magnetic resonance imaging revealed a small cerebral infarction in the left frontal lobe. Cerebral angiography revealed multi-vessel intracranial occlusive disease. Several days later, neurologic deterioration and aggravation of cerebral infarction developed due to a thyroid storm. A thyroid function test revealed the following: thyroid-stimulating hormone (TSH) ＜0.01 μunits/mL (reference range, 0.55-4.78 μunits/mL); triiodo-thyronine ＞8.0 ng/mL (reference range, 0.77-1.81 ng/mL); free thyroxine (T4) of 9.47 pmol/L (reference range, 11.4-22.6 pmol/L); and TSH receptor antibody of 37.10 U/L (reference range, 0-10 U/L). For thyroid storm management, we initiated treatment with methimazole, Gemstein's solution, and hydrocortisone. Finally, the thyroid disease was controlled, and neurologic deficits improved. We describe a case of acute cerebral infarction combined with a thyroid storm in a patient with Moyamoya syndrome and Graves' disease. Hyperthyroidism such as Graves' disease should be considered in the differential diagnosis for patho-etiologic mechanisms associated with MMS. A cerebrovascular disease with a thyroid storm can lead to severe mortality and morbidity. Prompt diagnosis and strict treatment are important.

INTRODUCTION

Moyamoya disease (MMD) is an uncommon, chronic cerebrovascular disease in which stenosis–occlusion of the bilateral internal carotid arteries follows the development of characteristic Moyamoya vasculature at the base of the brain [24]. People with a well-known related disorder are classified as having Moyamoya syndrome (MMS), whereas those with an idiopathic disease and no known risk factors are classified as having MMD. The well-recognized associated diseases are sickle cell anemia, Down syndrome, neurofibromatosis, and rarely, hyperthyroidism such as Grave’s disease (GD) [19]. Moyamoya vasculopathy combined with hyperthyroidism is an uncommon condition that causes ischemic stroke with thyrotoxicity. A thyroid storm, an endocrine condition associated with uncontrolled hyperthyroidism, in a patient with underlying Moyamoya syndrome (MMS) can lead to increased morbidity and mortality rates. Also, depending on the order of the disease in which Thyrotoxicosis, acute infarction, and MMD were diagnosed, the hospitalization department for endocrinology, neurology, and neurosurgery may vary. It is considered relatively difficult for neurosurgeons to experience. We report a case of acute cerebral infarction combined with a thyroid storm in a patient with MMS and GD.

CASE DESCRIPTION

A 43-year-old woman was admitted to a local hospital with weakness in her right side. Diffusion magnetic resonance imaging (MRI) showed a small cerebral infarction in the left frontal lobe (Fig. 1A). Conservative management was done with hydration and antiplatelet therapy. However, three days later, her neurologic condition deteriorated. Her right-sided weakness was aggravated with newly developed left-sided weakness and dysarthria. Also, her level of consciousness became stuporous. She was transferred to our institution.

Fig. 1.

Brain magnetic resonance imaging. (A) initial diffusion image, (B) aggravated diffusion image. Cerebral infarction territory at both frontal lobes was increased.

On arrival at our institution, her Glasgow Coma Scale (GCS) score was 9 (E2V2M5). Her motor grades were upper extremities III/I and lower extremities IV/III. Her blood pressure was 175/80 mmHg with a heart rate of 150 beats/min, and her electrocardiography (ECG) indicated atrial fibrillation with a rapid ventricular response (RVR). A follow-up MRI, including a diffusion and perfusion sequence, was conducted. Compared with the previous MRI findings, the infarction territory was markedly increased (Fig. 1B). Cerebral angiography was subsequently performed. It revealed occlusion of both distal ICAs, with the characteristics of Moyamoya vessels and poor collateral flow in both frontal lobes. These angiographic findings were most compatible with a diagnosis of MMD (Fig. 2). The patient underwent conservative treatment, including hydration and antiplatelet therapy in the intensive care unit. A few days later, she had a sudden seizure. Her vital signs indicated high blood pressure and tachycardia, with a fever of up to 38.5℃. Electrocardiography revealed atrial fibrillation with RVR, and chest radiography showed cardiomegaly. Her seizure was controlled by an anticonvulsant. Simultaneously, rhythm and rate control therapy with amiodarone and beta-blockers was used to stabilize the blood pressure and heart rate and achieve chemical de-fibrillation. An interview with her family revealed that she had a history of hyperthyroidism. A thyroid function test was done, and it revealed the following: thyroid-stimulating hormone (TSH)＜0.01 µunits/mL (reference range, 0.55–4.78 µunits/mL); triiodo-thyronine＞8.0 ng/mL (reference range, 0.78–1.81 ng/mL); free thyroxine (T4) of 9.47 pmol/L (reference range, 11.4–22.6 pmol/L); and TSH receptor antibody of 37.10 U/L (reference range, 0–10 U/L). By consultation with an endocrinologist, we diagnosed a thyroid storm. The thyroid storm score (Burch and Wartofsky score) was 85 points. We initiated management of the thyroid dysfunction with methimazole, Gemstein’s solution, and hydrocortisone. The patient was transferred to the general ward after three weeks of intensive care, and her neurological condition improved with rehabilitation. At discharge, her level of consciousness was drowsy, and her motor power grades were upper extremities III/II and lower extremities III/II. Six months later, her level of consciousness was alert. Her mini-mental state examination (MMSE) score was 27/30. Her motor grades were upper V/IV and lower V/V. The modified Barthel active daily living (ADL) index was 91/100. Medications for GD and epilepsy were continued.

Fig. 2.

Cerebral angiography. (A) Right internal cerebral artery (ICA), (B) Left ICA, (C) Left vertebral artery. Steno-occlusion of bilateral distal ICA with moyamoya vessels.

DISCUSSION

GD is unusually complicated by Moyamoya vasculopathy, resulting in an ischemic stroke with thyrotoxicity [11,17]. The association of GD with MMD was first reported by Kushima et al., who documented two cases of patients presenting with clinical symptoms of thyrotoxicosis, followed by strokes [10]. Until recently, approximately 50 cases of co-occurring GD and MMD had been described in the literature [20].

GD, known as a toxic, diffuse goiter, is an autoimmune disease that affects the thyroid and is the most common cause of hyperthyroidism [2]. The Irish surgeon Robert Graves first described the condition in 1835 [15]. It is affected by thyroid-stimulating immunoglobulin (TSI), which is similar to thyroid-stimulating hormone (TSH). The TSI antibodies induce the thyroid gland to secrete excess thyroid hormones. GD occurs in about 3% of females and 0.5% of males [2]. It most often begins between the ages of 40 and 60 but can begin at any age. The definitive cause is unknown; however, it is believed to include a combination of environmental and genetic factors [12]. This disease may occur as a response to physical or emotional stress or infection [1].

Although the pathogenesis of MMD with GD is not well known, it has been suggested that the autoimmune mechanisms involved in the development of GD and overactivation of the sympathetic nervous system in a hyperthyroid state play essential roles in the occurrence of steno-occlusive lesions in the intracranial arteries [16]. Other disorders combined with MMS, including antiphospholipid syndrome, systemic lupus erythematosus, tuberculosis, leptospirosis, ulcerative colitis, and post-radiation arteritis, have well-defined autoimmune mechanisms of pathogenesis or are connected with arteritis that affects the cerebral arteries [22]. Even non-vasculitic diseases like Down syndrome, which is related to MMS, may be associated with autoimmune etiologies [9].

Our patient had a history of GD but was not taking medication for the disease, making the risk of developing a thyroid storm very high. Generally, thyroid storms are uncommon, but the complication of hyperthyroidism has high mortality and severity. A high fever (often above 40°C), fast and often irregular heartbeats, elevated blood pressure, vomiting, diarrhea, and agitation are symptoms of thyroid storms [14]. Thyroid storms are typically triggered by stressful medical conditions, such as uncontrolled hyperthyroidism, cessation of anti-thyroid drugs, surgery, trauma, infection, and diabetic ketoacidosis [18]. The pathophysiological mechanisms of thyroid storms are combinations of sharp increases in the secretion of thyroid hormones, relative adrenal insufficiency, hyperactivity of the sympathetic nervous system, and increased peripheral cellular reactions to thyroid hormones. Thyroid storms are characterized by the dysfunction of multiple organ systems, such as the gastrointestinal system, cardiovascular system, hepatic system, thermoregulatory system, and central nervous system [3], and are related to thromboembolic events. Atrial fibrillation and ventricular dysrhythmias associated with hyperthyroidism have a high risk of leading to a cardioembolic stroke [23]. Mortality is associated with shock, multiple organ failure, or disseminated intravascular coagulation (DIC) [18]. The overall mortality rate of cardioembolic strokes is between 10% and 30%. In a thyrotoxicotic state, overproduction of thyroid hormones can affect vascular reactivity and cause cerebral perfusion dysfunction. Therefore, activities related to thyrotoxicosis affect ischemic cerebrovascular symptoms in MMD [5,21]. In our study, the neurological symptoms of the patient worsened three days after the stress caused by the preceding ischemic stroke, and their neurological symptoms improved after treatment of the thyroid storm with methimazole, Gemstein’s solution, and hydrocortisone. Table 1 summarizes the clinical and radiologic data, treatment and outcomes, for similar cases reported earlier [4-8,11,13]. Jang et al. reported that a 41-year-old woman diagnosed with a thyroid storm during an acute cerebral infarction of 90 points on the Burch and Wartofsky scale. After intensive treatment for the thyroid storm, the seizures, unexplained fever, and neurologic symptoms improved [7]. Kang et al. also reported a similar case in which thyrotoxicosis aggravated the acute cerebral infarction caused by MMD [8].

Table 1.

Summary of clinical data of all eight patients.

Case	Age (Years)/Sex	Presentation	Thyroid condition at neurologic aggravation	MRI findings	Angiography findings	Treatment (Thyroid / CVD)	Outcome	Reference number
1	41/F	Left hemiparesis and dysarthria	Thyrotoxic	Right thalamus and occipital infarct	Total occlusion of bilateral distal ICA and right PCA	Propylthiouracil Lugol's solution/Antiplatelet therapy	Good	21
2	41/F	Right hemiparesis and aphasia	Thyrotoxic	Left MCA territory infarct	Total occlusion of bilateral distal ICA	Methimazole Lugol's solution/Antiplatelet therapy	Good	22
3	23/F	Left hemiparesis and hypesthesia	Thyrotoxic	Right temporal-parietal infarct	Multiple intracranial stenosis around Circle of Willis	Propylthiouracil/Aspirin	Good	4
4	10/F	Left hemiparesis	Thyrotoxic	Right frontal/parietal infarct; left frontal infarct	Total occlusion of bilateral ICA and stenosis of proximal ACA/MCA	Thyroid radio-ablation/Aspirin	Good	24
5	54/F	Right hemiparesis and hypesthesia	Thyrotoxic	Left frontal infarct	Multiple intracranial stenosis around Circle of Willis	ATM/bilateral STA-MCA bypass; EMS	Good	25
6	16/F	TIA	Thyrotoxic	Right posterior border zone	Bilateral net-like vessels	ATM/STA-MCA bypass	Not described	20
7	37/F	Ischemic stroke	Thyrotoxic	Left MCA territory infarct	No obvious stenosis	ATM/Warfarin	Right mild hemiparesis	23
8	43/F	Right hemiparesis	Thyrotoxic	Right frontal infarct	Total occlusion of bilateral ICA and poor collateral vessel in both frontal lobes	Methimazole Gemstein's solution/Aspirin	Good	Our case

F, female; TIA, transient ischemic attack; MCA, middle cerebral artery; ICA, internal carotid artery; PCA, posterior cerebral artery; ACA, anterior cerebral artery; ATM, antithyroid medication; EMS, encephalomyosynangiosis

Our study case is uncommon. However, prompt diagnosis and management are essential for improving the prognoses of MMD and GD patients who have experienced ischemic strokes. Ischemic cerebrovascular events can be risk factors for thyroid storms. If cerebral infarction or transient ischemic attacks develop in a patient with combined GD and MMD, treatment should be initiated immediately. Also, maintenance of a long-term euthyroid state is essential for preventing a relapse of hyperthyroidism after normal thyroid function has been restored in MMD patients. Treatment modalities for patients in our facility include oral anti-thyroid medications, antiplatelet agents, and corticosteroids. Management of GD is essential to prevent recurrence, but Moyamoya vasculopathy may progress even in controlled GD [6].

CONCLUSIONS

We report an uncommon case of acute cerebral infarction combined with a thyroid storm in a patient with MMS and GD. It should be noted that the simultaneous occurrence of a thyroid storm and cerebrovascular accident in MMS and GD highly elevates mortality and morbidity. Prompt diagnosis and aggressive treatment are essential for saving a patient’s life. Therefore, if neurological symptoms occur in patients with histories of combined MMD and GD, neurosurgeons should contemplate thyroid function tests for identifying thyroid storms, and aggressive treatment should be initiated.