Enzo Errichetti1, Shamir Geller2, Iris Zalaudek3, Caterina Longo4, Athanassios Kyrgidis5, Bengu Nisa Akay6, Vincenzo Piccolo7, Patricia Myskowski8, Paola Vitiello7, Teresa Russo7, Giuseppe Argenziano7, Martyna Sławińska9, Małgorzata Sokołowska-Wojdyło9, Michał Sobjanek9, Ruzica Jurakic Toncic10, Jaka Rados10, Daniela Ledic Drvar10, Romana Ceovic10, Grażyna Kaminska-Winciorek11, Pedro Zaballos12, Camilla Reggiani13, Zorana Kremic14, Sven Lanssens15, Ayşe Tülin Güleç16, Alejandro Lobato-Berezo17, Giovanni Damiani18, Vincenzo Maione19, Piergiacomo Calzavara-Pinton19, Elena Sotiriou20, Giuseppe Stinco21, Zoe Apalla22, Aimilios Lallas20. 1. Institute of Dermatology, Department of Medicine, University of Udine, Udine, Italy. Electronic address: enzoerri@yahoo.it. 2. Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Division of Dermatology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 3. Department of Dermatology and Venereology, Dermatology Clinic, Maggiore Hospital, University of Trieste, Trieste, Italy. 4. Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy; Azienda Sanitaria Locale, IRCCS di Reggio Emilia, Centro Oncologico ad Alta Tecnologia Diagnostica-Dermatologia, Reggio Emilia, Italy. 5. Department of Oral & Maxillofacial Surgery, Aristotle University, Thessaloniki, Greece. 6. Ankara University School of Medicine, Ankara, Turkey. 7. Dermatology Unit, University of Campania, Naples, Italy. 8. Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. 9. Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, Gdańsk, Poland. 10. University Department of Dermatology and Venereology, University Hospital Centre and School of Medicine, Zagreb, Croatia. 11. Department of Bone Marrow Transplantation and Onco-Hematology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland. 12. Dermatology Department, Hospital Sant Pau i Santa Tecla, Tarragona, Spain. 13. Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy. 14. Department of Dermatology and Venereology, Military Medical Academy, Belgrade, Serbia. 15. Dermatologie Maldegem, Maldegem, Belgium. 16. Department of Dermatology and Venereology, Başkent University Faculty of Medicine, Ankara, Turkey. 17. Hospital del Mar-Parc de Salut Mar, Barcelona, Spain. 18. Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. 19. Department of Dermatology, Spedali Civili, University of Brescia, Brescia, Italy. 20. First Department of Dermatology, Aristotle University, Thessaloniki, Greece. 21. Institute of Dermatology, Department of Medicine, University of Udine, Udine, Italy. 22. Second Department of Dermatology, Aristotle University, Thessaloniki, Greece.
Abstract
BACKGROUND: Limited data on dermatoscopy of nodular/plaque-type T-/B-cell primary cutaneous lymphomas (PCLs) is available. OBJECTIVE: To describe dermatoscopic features of nodular/plaque-type PCLs, comparing them with those of clinical mimickers (pseudolymphomas, tumors, and inflammatory lesions) and investigating possible differences according to histologic subtypes. METHODS: Participants were invited to join this retrospective, multicenter case-control study by submitting histologically/immunohistochemically confirmed instances of nodular/plaque-type PCLs and controls. Standardized assessments of the dermatoscopic images and comparative analyses were performed. RESULTS: A total of 261 lesions were included (121 PCLs and 140 controls). Orange structureless areas were the strongest PCL dermatoscopic predictor on multivariate analysis compared with tumors and noninfiltrative inflammatory dermatoses. On the other hand, a positive association was found between PCLs and either unfocused linear vessels with branches or focal white structureless areas compared with infiltrative inflammatory dermatoses, whereas white lines were predictive of PCLs over pseudolymphomas. Differences in the vascular pattern were also seen between B- and T-cell PCLs and among B-cell PCL subtypes. LIMITATIONS: Retrospective design and the lack of a dermatoscopic-pathologic correlation analysis. CONCLUSION: Nodular/plaque-type PCLs display dermatoscopic clues, which may partially vary according to histologic subtype and whose diagnostic relevance depends on the considered clinical differential diagnoses.
BACKGROUND: Limited data on dermatoscopy of nodular/plaque-type T-/B-cell primary cutaneous lymphomas (PCLs) is available. OBJECTIVE: To describe dermatoscopic features of nodular/plaque-type PCLs, comparing them with those of clinical mimickers (pseudolymphomas, tumors, and inflammatory lesions) and investigating possible differences according to histologic subtypes. METHODS: Participants were invited to join this retrospective, multicenter case-control study by submitting histologically/immunohistochemically confirmed instances of nodular/plaque-type PCLs and controls. Standardized assessments of the dermatoscopic images and comparative analyses were performed. RESULTS: A total of 261 lesions were included (121 PCLs and 140 controls). Orange structureless areas were the strongest PCL dermatoscopic predictor on multivariate analysis compared with tumors and noninfiltrative inflammatory dermatoses. On the other hand, a positive association was found between PCLs and either unfocused linear vessels with branches or focal white structureless areas compared with infiltrative inflammatory dermatoses, whereas white lines were predictive of PCLs over pseudolymphomas. Differences in the vascular pattern were also seen between B- and T-cell PCLs and among B-cell PCL subtypes. LIMITATIONS: Retrospective design and the lack of a dermatoscopic-pathologic correlation analysis. CONCLUSION: Nodular/plaque-type PCLs display dermatoscopic clues, which may partially vary according to histologic subtype and whose diagnostic relevance depends on the considered clinical differential diagnoses.