| Literature DB >> 34690147 |
Qiang Zhang1, Jordan L Schultz1,2, Georgina M Aldridge1, Jacob E Simmering3, Youngcho Kim1, Amy C Ogilvie2,4, Nandakumar S Narayanan1.
Abstract
Previous studies have identified dementia as a risk factor for death from coronavirus disease 2019 (COVID-19). However, it is unclear whether Alzheimer's disease (AD) is an independent risk factor for COVID-19 case fatality rate. In a retrospective cohort study, we identified 387,841 COVID-19 patients through TriNetX. After adjusting for demographics and comorbidities, we found that AD patients had higher odds of dying from COVID-19 compared to patients without AD (Odds Ratio: 1.20, 95%confidence interval: 1.09-1.32, p < 0.001). Interestingly, we did not observe increased mortality from COVID-19 among patients with vascular dementia. These data are relevant to the evolving COVID-19 pandemic.Entities:
Keywords: Alzheimer’s disease; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2); case fatality; dementia with Lewy bodies; frontotemporal dementia; vascular dementia
Mesh：
Year: 2021 PMID： 34690147 PMCID： PMC8841099 DOI： 10.3233/JAD-215161
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.160