Literature DB >> 34689290

The Role of Long Non-coding RNA, Nuclear Enriched Abundant Transcript 1 (NEAT1) in Cancer and Other Pathologies.

Miao Zhang1, Jianmin Guo1, Lifei Liu1, Mei Huang1, Yuexuan Li1, Samuel Bennett2, JiaKe Xu2, Jun Zou3.   

Abstract

Nuclear enriched abundant transcript 1 (NEAT1), consisting of two kinds of lncRNAs of 3.7 kB NEAT1-1 and 23 kB NEAT1-2, can be highly expressed in organs and tissues such as the ovary, prostate, colon, and pancreas, and is involved in paraspeckle formation and mRNA editing and gene expression. Therefore, NEAT1 is a potential biomarker for the treatment of a variety of diseases, which may be caused by two factors (isoforms of NEAT1 and NEAT1 sponging miRNA as ceRNA). However, there is still much confusion about the mechanism and downstream effector between the abnormal expression of NEAT1 and various diseases. This review summarizes recent research progress on NEAT1 in cancer and other pathologies and provides a more reliable theoretical basis for the treatment of related diseases.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Cancer; NEAT1; Noncancerous; lncRNAs

Mesh：

Substances：

Year:  2021        PMID： 34689290     DOI： 10.1007/s10528-021-10138-8

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  135 in total

1.  p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity.

Authors:  Carmen Adriaens; Laura Standaert; Jasmine Barra; Mathilde Latil; Annelien Verfaillie; Peter Kalev; Bram Boeckx; Paul W G Wijnhoven; Enrico Radaelli; William Vermi; Eleonora Leucci; Gaëlle Lapouge; Benjamin Beck; Joost van den Oord; Shinichi Nakagawa; Tetsuro Hirose; Anna A Sablina; Diether Lambrechts; Stein Aerts; Cédric Blanpain; Jean-Christophe Marine
Journal:  Nat Med       Date:  2016-07-04       Impact factor: 53.440

2.  p53-dependent non-coding RNA networks in chronic lymphocytic leukemia.

Authors:  C J Blume; A Hotz-Wagenblatt; J Hüllein; L Sellner; A Jethwa; T Stolz; M Slabicki; K Lee; A Sharathchandra; A Benner; S Dietrich; C C Oakes; P Dreger; D te Raa; A P Kater; A Jauch; O Merkel; M Oren; T Hielscher; T Zenz
Journal:  Leukemia       Date:  2015-05-14       Impact factor: 11.528

3.  Postmenopausal Osteoporosis.

Authors:  Dennis M Black; Clifford J Rosen
Journal:  N Engl J Med       Date:  2016-05-26       Impact factor: 91.245

4.  Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.

Authors:  Alfredo Castello; Bernd Fischer; Katrin Eichelbaum; Rastislav Horos; Benedikt M Beckmann; Claudia Strein; Norman E Davey; David T Humphreys; Thomas Preiss; Lars M Steinmetz; Jeroen Krijgsveld; Matthias W Hentze
Journal:  Cell       Date:  2012-05-31       Impact factor: 41.582

5.  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.

Authors:  Freddie Bray; Jacques Ferlay; Isabelle Soerjomataram; Rebecca L Siegel; Lindsey A Torre; Ahmedin Jemal
Journal:  CA Cancer J Clin       Date:  2018-09-12       Impact factor: 508.702

6.  The translational expression of ABCA2 and ABCA3 is a strong prognostic biomarker for multidrug resistance in pediatric acute lymphoblastic leukemia.

Authors:  Narges Aberuyi; Soheila Rahgozar; Zohreh Khosravi Dehaghi; Alireza Moafi; Andrea Masotti; Alessandro Paolini
Journal:  Onco Targets Ther       Date:  2017-07-10       Impact factor: 4.147

Review 7.  NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?

Authors:  Haiyan An; Non G Williams; Tatyana A Shelkovnikova
Journal:  Noncoding RNA Res       Date:  2018-11-15

Review 8.  LncRNA NEAT1: Shedding light on mechanisms and opportunities in liver diseases.

Authors:  Fang-Tian Bu; Ao Wang; Yan Zhu; Hong-Mei You; Ya-Fei Zhang; Xiao-Ming Meng; Cheng Huang; Jun Li
Journal:  Liver Int       Date:  2020-10-13       Impact factor: 5.828

9.  Knockdown of long non-coding RNA NEAT1 relieves the inflammatory response of spinal cord injury through targeting miR-211-5p/MAPK1 axis.

Authors:  Qing An; Zipeng Zhou; Yi Xie; Yu Sun; Haixiang Zhang; Yang Cao
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269
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  2 in total

1.  Multidimension Analysis of the Prognostic Value, Immune Regulatory Function, and ceRNA Network of LY6E in Individuals with Colorectal Cancer.

Authors:  Ting Li; Weidong Liu; Chun Wang; Man Wang; Wenjia Hui; Jiajie Lu; Feng Gao
Journal:  J Immunol Res       Date:  2022-03-11       Impact factor: 4.818

2.  Long Non-Coding RNA MAFG-AS1 as a Potential Biomarker for Hepatocellular Carcinoma: Linkage with Tumor Features, Markers, Liver Functions, and Survival Profile.

Authors:  Yuanyuan Tian; Jiao Wang; Ge Tian; Bing Li; Moli Chen; Xiaoning Sun
Journal:  Front Surg       Date:  2022-05-17
  2 in total

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